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细菌脂多糖激活抑制性B淋巴细胞。

Bacterial lipopolysaccharide activates suppressor B lymphocytes.

作者信息

Koenig S, Hoffmann M K

出版信息

Proc Natl Acad Sci U S A. 1979 Sep;76(9):4608-12. doi: 10.1073/pnas.76.9.4608.

DOI:10.1073/pnas.76.9.4608
PMID:159461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC411628/
Abstract

Lipopolysaccharide (LPS) extracted from the outer cell wall of Gram-negative bacteria modulates the immune response in vivo and in vitro. Depending on the experimental conditions, it may enhance or inhibit the production of humoral antibody. The pathway by which LPS suppresses antibody production is examined in this study. C57BL/6 spleen cells incubated with LPS (greater than 10 micrograms/ml) not only fail to produce antibody to sheep erythrocytes in vitro but also, when transferred 24 hr after stimulation with LPS, inhibit antibody production in spleen cells that were not treated with LPS. This observation suggested that LPS activates suppressor cells. We have identified a suppressor B cell as mediator of LPS-induced immune suppression and determined its cell surface antigen phenotype as Ig+, Ia+, CR+, Ly-B-2+,PC1-.LPS does not induce suppressor macrophages or suppressor T cells, nor are macrophages or T cells required for the generation of suppressor B cells by LPS.

摘要

从革兰氏阴性菌外细胞壁提取的脂多糖（LPS）可在体内和体外调节免疫反应。根据实验条件的不同，它可能增强或抑制体液抗体的产生。本研究探讨了LPS抑制抗体产生的途径。用LPS（大于10微克/毫升）孵育的C57BL/6脾细胞不仅在体外不能产生抗绵羊红细胞抗体，而且在LPS刺激24小时后转移时，还会抑制未用LPS处理的脾细胞中的抗体产生。这一观察结果表明LPS激活了抑制细胞。我们已确定一种抑制性B细胞是LPS诱导免疫抑制的介质，并确定其细胞表面抗原表型为Ig+、Ia+、CR+、Ly-B-2+、PC1-。LPS不会诱导抑制性巨噬细胞或抑制性T细胞，LPS产生抑制性B细胞也不需要巨噬细胞或T细胞。

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本文引用的文献

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