Zhong Yu-Chen, Wang Shi-Chun, Han Yin-He, Wen Yu
Department of Histology and Embryology, College of Basic Medical Sciences, China Medical University, Shenyang 110122, China.
Class 4, Phase 102, China Medical University, Shenyang 110122, China.
Stem Cells Int. 2020 Mar 7;2020:2560174. doi: 10.1155/2020/2560174. eCollection 2020.
Infrapatellar fat pad (IPFP) can be easily obtained during knee surgery, which avoids the damage to patients for obtaining IPFP. Infrapatellar fat pad adipose-derived stem cells (IPFP-ASCs) are also called infrapatellar fat pad mesenchymal stem cells (IPFP-MSCs) because the morphology of IPFP-ASCs is similar to that of bone marrow mesenchymal stem cells (BM-MSCs). IPFP-ASCs are attracting more and more attention due to their characteristics suitable to regenerative medicine such as strong proliferation and differentiation, anti-inflammation, antiaging, secreting cytokines, multipotential capacity, and 3D culture. IPFP-ASCs can repair articular cartilage and relieve the pain caused by osteoarthritis, so most of IPFP-related review articles focus on osteoarthritis. This article reviews the anatomy and function of IPFP, as well as the discovery, amplification, multipotential capacity, and application of IPFP-ASCs in order to explain why IPFP-ASC is a superior stem cell source in regenerative medicine.
髌下脂肪垫（IPFP）在膝关节手术中易于获取，避免了为获取IPFP对患者造成的损伤。髌下脂肪垫脂肪来源干细胞（IPFP - ASCs）也被称为髌下脂肪垫间充质干细胞（IPFP - MSCs），因为IPFP - ASCs的形态与骨髓间充质干细胞（BM - MSCs）相似。IPFP - ASCs因其具有适合再生医学的特性，如强大的增殖和分化能力、抗炎、抗衰老、分泌细胞因子、多能性以及三维培养等，而受到越来越多的关注。IPFP - ASCs可以修复关节软骨并缓解骨关节炎引起的疼痛，因此大多数与IPFP相关的综述文章都聚焦于骨关节炎。本文综述了IPFP的解剖结构和功能，以及IPFP - ASCs的发现、扩增、多能性和应用，以解释为什么IPFP - ASC是再生医学中一种优越的干细胞来源。
