Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK.
North West Lung Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Thorax. 2020 Jun;75(6):520-527. doi: 10.1136/thoraxjnl-2019-214484. Epub 2020 Mar 26.
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.
慢性阻塞性肺疾病（COPD）的急性加重与显著的死亡率、健康和经济负担相关。其诊断、评估和管理数十年来一直不尽人意，没有改变。最近的临床和转化研究表明，通过病因学分组可以解决加重的机制和结果的显著异质性。这有望促进对每种类型加重背后的生物学过程的更好理解，并允许引入可以改善结果的精准医疗干预措施。这篇综述总结了 COPD 加重的诊断、表型、靶向治疗和预防方面的新数据。
