Murphy Rachel
Cancer Control Research, BC Cancer, 2-107 675 West 10th Avenue, Vancouver, BC V5Z 1L3, Canada.
School of Population and Public Health, University of British Columbia, 167-2206 East Mall, Vancouver, BC V6T 1Z3, Canada.
Metabolites. 2020 Mar 25;10(4):123. doi: 10.3390/metabo10040123.
The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates 'omics' data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet-cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet-cancer relationships with multi-omic approaches are also discussed.
尽管在过去几十年中有大量证据且建议总体一致，但公众和健康专业人士往往对饮食与癌症之间的关系持怀疑态度。一种整合了代谢组学、遗传学、宏基因组学、转录组学和蛋白质组学等“组学”数据的系统生物学方法，有望更好地理解饮食如何影响癌症，并通过生物标志物发现改进饮食评估，从而恢复人们对饮食与癌症关联的信心。本文综述讨论了多组学方法在饮食与癌症研究中的应用。还讨论了为促进采用多组学方法研究饮食与癌症关系而需要解决的注意事项和挑战。
