Yasuda S, Mizuno N, Kawabe Y, Sakakibara S
Department of Dermatology, Nagoya City University Medical School, Japan.
Photodermatol. 1988 Oct;5(5):206-10.
A 58-year-old man developed a lichenoid reaction on light-exposed areas and subacute prurigo separate from the sun-exposed areas after receiving 200 mg of carbamazepine daily for one year. The difference action spectrum for erythema with or without ingesting the drug ranged from 250 to 390 nm with peaks at 260 and 290 nm. A positive photoingestion test was obtained after administering 2 mg of carbamazepine orally in one dose. Patch test with carbamazepine was negative, while photopatch test with carbamazepine was positive. Positive intracutaneous test was obtained with an irradiated mixture of human serum albumin and carbamazepine at 24 h and 48 h after injection. This patient appeared to be a case of photosensitive lichenoid reaction accompanied by nonphotosensitive subacute prurigo caused by carbamazepine.
一名58岁男性在每日服用200毫克卡马西平一年后，在光照部位出现苔藓样反应，在非光照部位出现亚急性痒疹。服用或未服用该药物时红斑的差异作用光谱范围为250至390纳米，峰值在260和290纳米。口服2毫克卡马西平一次后进行的光摄入试验呈阳性。卡马西平斑贴试验为阴性，而卡马西平光斑贴试验为阳性。注射人血清白蛋白和卡马西平的辐照混合物后24小时和48小时进行的皮内试验呈阳性。该患者似乎是一例由卡马西平引起的光敏性苔藓样反应伴非光敏性亚急性痒疹。
