Matiushenko Valeriia, Kutasevych Yanina, Jafferany Mohammad
Dermatology and Venereology, State Establishment "Institute of Dermatology and Venerеology of National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.
National Academy of Medical Sciences of Ukraine, State Establishment "Institute of Dermatology and Venerеology of National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.
Dermatol Ther. 2020 May;33(3):e13337. doi: 10.1111/dth.13337. Epub 2020 Apr 15.
The role of psychological factors in the manifestation and exacerbation of psoriasis is well known. Acute and chronic stress, anxiety, and depression affect the reactions of innate and acquired immunity. The exacerbations of psoriatic lesions are accompanied by increased production of inflammatory mediators, which could contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. The role of inhibitory neurotransmitters in the serum of patients with psoriasis exacerbation with comorbid emotional disorders is assessed. Forty patients with psoriasis in the exacerbation stage were examined. Spielberger State-Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI) scale were used to assess anxiety and depression parameters. We also evaluated the concentration of serotonin and gamma-aminobutyric acid (GABA) in the serum. Patients with psoriasis had significant anxiety and depressive disorders. An imbalance in serotonin levels and a decrease in serum GABA levels in patients with psoriasis in the acute stage were noted. Only patients with anxiety disorder had increased serotonin levels. Our findings suggest that the imbalance of neurotransmitters in patients with psoriasis in the acute stage is important in predicting the development of the emotional well-being.
心理因素在银屑病的表现和加重过程中的作用已广为人知。急性和慢性应激、焦虑及抑郁会影响先天免疫和后天免疫反应。银屑病皮损的加重伴随着炎症介质产生增加，这可能导致神经递质失衡以及抑郁和焦虑症状的出现。评估了伴有共病情绪障碍的银屑病加重患者血清中抑制性神经递质的作用。对40例处于加重期的银屑病患者进行了检查。使用斯皮尔伯格状态-特质焦虑量表（STAI）和贝克抑郁量表（BDI）评估焦虑和抑郁参数。我们还评估了血清中5-羟色胺和γ-氨基丁酸（GABA）的浓度。银屑病患者存在明显的焦虑和抑郁障碍。注意到急性期银屑病患者血清5-羟色胺水平失衡且血清GABA水平降低。只有焦虑症患者的5-羟色胺水平升高。我们的研究结果表明，急性期银屑病患者神经递质失衡对预测情绪健康状况的发展具有重要意义。
