Zupo Roberta, Lampignano Luisa, Lattanzio Antonio, Mariano Francesco, Osella Alberto R, Bonfiglio Caterina, Giannelli Gianluigi, Pergola Giovanni De
Population Health Unit, "Salus in Apulia Study" National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Italy.
Clinical Nutrition Unit, Medical Oncology, Department of Biomedical Science and Human Oncology, School of Medicine, University of Bari, Bari, Italy.
Int J Food Sci Nutr. 2020 Nov;71(7):884-890. doi: 10.1080/09637486.2020.1744533. Epub 2020 Mar 29.
Vitamin D improves bone density and latest studies show adherence to Med-Diet as protective on osteoporosis. This observational study aimed at investigating the relationship between 25(OH)D levels and adherence to Med-Diet. Body weight, BMI, WC, glucose, insulin, 25(OH)D, total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides, uric acid, and creatinine serum levels and insulin resistance were determined in 284 overweight/obese subjects not taking medications or supplements. Adherence to Med-Diet was evaluated by using PREDIMED score. High-level of adherence stood out. 25(OH)D was inversely related to BMI, WC, HOMA-IR, serum insulin and triglycerides, while directly to PREDIMED score. Two different regression models confirmed this positive correlation independently of gender and other parameters showing univariate relationship with 25(OH)D. This study argues that a closer adherence to Med-Diet is independently associated with an increase of 25(OH)D suggesting that higher vitamin D levels may contribute to the protective effect of the Med-Diet on osteoporosis.
维生素D可提高骨密度，最新研究表明坚持地中海饮食对骨质疏松症具有保护作用。这项观察性研究旨在调查25(OH)D水平与坚持地中海饮食之间的关系。对284名未服用药物或补充剂的超重/肥胖受试者测定了体重、体重指数、腰围、血糖、胰岛素、25(OH)D、总胆固醇、高密度和低密度脂蛋白胆固醇、甘油三酯、尿酸、肌酐血清水平以及胰岛素抵抗。采用PREDIMED评分评估对地中海饮食的坚持情况。高水平的坚持情况较为突出。25(OH)D与体重指数、腰围、稳态模型评估的胰岛素抵抗、血清胰岛素和甘油三酯呈负相关，而与PREDIMED评分呈正相关。两种不同的回归模型独立于性别和其他与25(OH)D呈单变量关系的参数证实了这种正相关。这项研究表明，更严格地坚持地中海饮食与25(OH)D的增加独立相关，这表明较高的维生素D水平可能有助于地中海饮食对骨质疏松症的保护作用。
