Department of Epidemiology, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Department of Biophysics, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia; Department of Physics, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110534. doi: 10.1016/j.msec.2019.110534. Epub 2019 Dec 6.
Metallic nanoparticles (NPs) possess unique properties which makes them attractive candidates for various applications especially in field of experimental medicine and drug delivery. Many approaches were developed to synthesize divers and customized metallic NPs that can be useful in many areas such as, experimental medicine, drug design, drug delivery, electrical and electronic engineering, electrochemical sensors, and biochemical sensors. Among different metallic nanoparticles, manganese (Mn) NPs are the most prominent materials, in the present study, we have synthetized unique MnZnDyEuFeO NPs by using ultrasonication method (x ≤ 0.1). The structure, and surface morphology of MnZnDyEuFeO NPs was characterized by XRD, SEM, TEM and EDX methods. We have examined the biological effects of MnZnDyEuFeO NPs on both normal (HEK-293) and cancerous (HCT-116) cells. We have found that the treatment of MnZnDyEuFeO NPs post 48 h, showed significant decline in cancer cells population as revealed by MTT assay. The IC value of MnZnDyEuFeO NPs was ranged between (2.35 μg/mL to 2.33 μg/mL). To check the specificity of the actions, we found that the treatment of MnZnDyEuFeO NPs did not produce any effects on the normal cells, which suggest that MnZnDyEuFeO NPs selectively targeted the cancerous cells. The anti-bacterial properties of MnZnDyEuFeO NPs were also evaluated by MIC and MBC assays. We suggest that MnZnDyEuFeO NPs produced by sonochemical method possess potential anti-cancer and anti-bacterial capabilities.
金属纳米粒子（NPs）具有独特的性质，这使得它们成为各种应用的理想候选者，特别是在实验医学和药物输送领域。已经开发出许多方法来合成多样化和定制的金属 NPs，这些 NPs 在实验医学、药物设计、药物输送、电子和电气工程、电化学传感器和生化传感器等许多领域都很有用。在不同的金属纳米粒子中，锰（Mn）NPs 是最突出的材料，在本研究中，我们通过超声法（x≤0.1）合成了独特的 MnZnDyEuFeO NPs。通过 XRD、SEM、TEM 和 EDX 方法对 MnZnDyEuFeO NPs 的结构和表面形貌进行了表征。我们研究了 MnZnDyEuFeO NPs 对正常（HEK-293）和癌细胞（HCT-116）的生物学效应。我们发现，MnZnDyEuFeO NPs 在处理 48 小时后，对癌细胞数量的减少有显著影响，这一点通过 MTT 试验得到证实。MnZnDyEuFeO NPs 的 IC 值在（2.35μg/mL 至 2.33μg/mL）之间。为了检查作用的特异性，我们发现 MnZnDyEuFeO NPs 的处理对正常细胞没有产生任何影响，这表明 MnZnDyEuFeO NPs 选择性地针对癌细胞。我们还通过 MIC 和 MBC 试验评估了 MnZnDyEuFeO NPs 的抗菌性能。我们认为，通过超声化学法制备的 MnZnDyEuFeO NPs 具有潜在的抗癌和抗菌能力。
