Mariage Pierre-Antoine, Hovhannisyan Areg, Panossian Alexander G
Botalys SA, 8 quai des usines, 7800 Ath, Belgium.
Sport Medicine and Antidoping Service Republican Centre, Yerevan 0001, Armenia.
Pharmaceuticals (Basel). 2020 Mar 29;13(4):57. doi: 10.3390/ph13040057.
The aim of this pilot study was to compare the efficacy of hydroponically cultivated red Meyer root preparation (HRG80) and traditionally harvested six-year-old white standard preparation (PGS) with placebo in preventing symptoms of stress.
The effects of HRG80, PGS, and placebo capsules were studied in 50 tired healthy subjects in a three-arm, randomized, double-blinded, placebo-controlled crossover trial. Efficacy-outcome measures included the accuracy of processing the d2 test for cognitive functions, obtained accuracy score in a computerized memory test, and the perceived-stress (PS) score.
A statistically significant interaction effect between time and treatment ( < 0.0001) was observed in the attention d2 and memory tests, indicating that HRG80 treatment was more beneficial than that with a placebo. The effects of PGS were better than those of the placebo, but the difference was not statistically significant. There was significant difference between the effects of HRG80 and PGS ( < 0.0001) that were observed after single (Day 1) and repeated administrations on Days 5 and 12 of treatment.
Overall, HRG80 treatment was significantly superior compared to that with the PGS and placebo regarding attention, memory, and PS scores after single and repeated administrations for 5 and 12 days.
本初步研究的目的是比较水培种植的红美人心草根提取物（HRG80）、传统采收的六年生白参标准提取物（PGS）与安慰剂在预防应激症状方面的疗效。
在一项三臂、随机、双盲、安慰剂对照的交叉试验中，对50名疲惫的健康受试者研究了HRG80、PGS和安慰剂胶囊的效果。疗效指标包括认知功能d2测试的处理准确性、计算机化记忆测试中获得的准确性得分以及感知应激（PS）得分。
在注意力d2测试和记忆测试中观察到时间与治疗之间存在统计学显著的交互作用（<0.0001），表明HRG80治疗比安慰剂更有益。PGS的效果优于安慰剂，但差异无统计学意义。在单次（第1天）给药以及治疗第5天和第12天重复给药后，观察到HRG80和PGS的效果存在显著差异（<0.0001）。
总体而言，在单次及连续5天和12天重复给药后，就注意力、记忆力和PS得分而言，HRG80治疗明显优于PGS和安慰剂。
