• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人参皂苷Rb1在神经系统疾病中的研究进展

Progress of Ginsenoside Rb1 in neurological disorders.

作者信息

Ling Gongxia, Zhang Min, Chen Chizhang, Wang Yan, Gao Qiqi, Li Jianshun, Yuan Hao, Jin Wenwen, Lin Wei, Yang Lingrong

机构信息

Department of Pediatrics, The Second School of Medicine, Wenzhou Medical University, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Department of Clinical Medicine, Pingyang County Traditional Chinese Medicine Hospital, Meizhou, Zhejiang, China.

出版信息

Front Pharmacol. 2024 Jan 24;15:1280792. doi: 10.3389/fphar.2024.1280792. eCollection 2024.

DOI:10.3389/fphar.2024.1280792
PMID:38327982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10847293/
Abstract

Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)-a protopanaxadiol saponin and a typical ginseng component-exhibits anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-autophagy properties in the nervous system. Neurological disorders remain a leading cause of death and disability globally. GsRb1 effectively treats neurological disorders. To contribute novel insights to the understanding and treatment of neurological disorders, we present a comprehensive review of the pharmacokinetics, actions, mechanisms, and research development of GsRb1 in neurological disorders.

摘要

人参常用于传统中医治疗神经系统疾病。人参的主要活性成分是人参皂苷，根据其化学结构已被分为110多种类型。人参皂苷Rb1（GsRb1）——一种原人参二醇皂苷和典型的人参成分——在神经系统中具有抗炎、抗氧化、抗凋亡和抗自噬特性。神经系统疾病仍然是全球死亡和残疾的主要原因。GsRb1能有效治疗神经系统疾病。为了对神经系统疾病的理解和治疗提供新的见解，我们对GsRb1在神经系统疾病中的药代动力学、作用、机制和研究进展进行了全面综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/211e2c9b7ed5/fphar-15-1280792-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/10e3bdc3c28e/FPHAR_fphar-2024-1280792_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/c536a69b28bc/fphar-15-1280792-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/d7c9587d183d/fphar-15-1280792-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/66af920ef0df/fphar-15-1280792-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/211e2c9b7ed5/fphar-15-1280792-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/10e3bdc3c28e/FPHAR_fphar-2024-1280792_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/c536a69b28bc/fphar-15-1280792-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/d7c9587d183d/fphar-15-1280792-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/66af920ef0df/fphar-15-1280792-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b194/10847293/211e2c9b7ed5/fphar-15-1280792-g004.jpg

相似文献

1
Progress of Ginsenoside Rb1 in neurological disorders.人参皂苷Rb1在神经系统疾病中的研究进展
Front Pharmacol. 2024 Jan 24;15:1280792. doi: 10.3389/fphar.2024.1280792. eCollection 2024.
2
Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals.游离型人参皂苷 Rb1 和纳米型人参皂苷 Rb1 对实验性动物尿酸盐诱导的痛风性关节炎的抗炎和抗痛风作用。
Chem Biol Interact. 2020 Dec 1;332:109285. doi: 10.1016/j.cbi.2020.109285. Epub 2020 Oct 7.
3
Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats.人参皂苷Rb1抑制铁死亡以改善新生大鼠缺氧缺血性脑损伤。
Int Immunopharmacol. 2023 Aug;121:110503. doi: 10.1016/j.intimp.2023.110503. Epub 2023 Jun 24.
4
Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like effect of ginsenoside Rb1, a major active ingredient of Panax ginseng C.A. Meyer.人参主要活性成分人参皂苷Rb1的抗抑郁样作用中5-羟色胺能、去甲肾上腺素能和多巴胺能系统的参与。
J Ethnopharmacol. 2017 May 23;204:118-124. doi: 10.1016/j.jep.2017.04.009. Epub 2017 Apr 13.
5
Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases.人参皂苷Rb1在中枢神经系统疾病中的神经保护机制
Front Pharmacol. 2022 Jun 2;13:914352. doi: 10.3389/fphar.2022.914352. eCollection 2022.
6
Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia-induced injuries in aged mice: Involvement of anti-oxidant signaling.人参皂苷Rb1预处理对老年小鼠严重脑缺血所致损伤的神经保护作用：抗氧化信号通路的参与
Geriatr Gerontol Int. 2017 Feb;17(2):338-345. doi: 10.1111/ggi.12699. Epub 2015 Dec 29.
7
Ginsenoside Rb1 inhibit apoptosis in rat model of Alzheimer's disease induced by Aβ.人参皂苷Rb1抑制由Aβ诱导的阿尔茨海默病大鼠模型中的细胞凋亡。
Am J Transl Res. 2018 Mar 15;10(3):796-805. eCollection 2018.
8
Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis.人参皂苷 Rb1 作为一种抗糖尿病药物及其作用机制分析。
Cells. 2019 Feb 28;8(3):204. doi: 10.3390/cells8030204.
9
Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract.口服红参提取物后人参皂苷 Rb1 及其代谢产物化合物 K 的药代动力学。
J Ginseng Res. 2013 Oct;37(4):451-6. doi: 10.5142/jgr.2013.37.451.
10
Protective Effect of Ginsenoside Rb1 on Hydrogen Peroxide-induced Oxidative Stress in Rat Articular Chondrocytes.人参皂苷 Rb1 对过氧化氢诱导的大鼠关节软骨细胞氧化应激的保护作用。
J Ginseng Res. 2012 Apr;36(2):161-8. doi: 10.5142/jgr.2012.36.2.161.

引用本文的文献

1
Cerebral ischemia-reperfusion injury: mechanisms and promising therapies.脑缺血再灌注损伤：机制与前景广阔的治疗方法
Front Pharmacol. 2025 Jul 16;16:1613464. doi: 10.3389/fphar.2025.1613464. eCollection 2025.
2
Unlocking ginsenosides' therapeutic power with polymer-based delivery systems: current applications and future perspectives.利用基于聚合物的递送系统释放人参皂苷的治疗潜力：当前应用与未来展望。
Front Pharmacol. 2025 Jul 10;16:1629803. doi: 10.3389/fphar.2025.1629803. eCollection 2025.
3
Overcoming acquired immunotherapy resistance in non-small cell lung cancer using ginsenoside Rb1-loaded, peptide-enhanced exosome delivery systems.

本文引用的文献

1
The interaction between ginseng and gut microbiota.人参与肠道微生物群之间的相互作用。
Front Nutr. 2023 Nov 17;10:1301468. doi: 10.3389/fnut.2023.1301468. eCollection 2023.
2
Regulation of NAD/NADH Redox Involves the Protective Effects of Ginsenoside Rb1 against Oxygen-Glucose Deprivation/Reoxygenation-Induced Astrocyte Lesions.调节 NAD/NADH 氧化还原涉及人参皂苷 Rb1 对氧葡萄糖剥夺/再氧合诱导的星形胶质细胞损伤的保护作用。
Int J Mol Sci. 2023 Nov 7;24(22):16059. doi: 10.3390/ijms242216059.
3
Cognitive Impairment in Parkinson's Disease: An Updated Overview Focusing on Emerging Pharmaceutical Treatment Approaches.
使用负载人参皂苷Rb1的、肽增强的外泌体递送系统克服非小细胞肺癌中的获得性免疫治疗耐药性
J Nanobiotechnology. 2025 Jun 13;23(1):443. doi: 10.1186/s12951-025-03456-1.
4
Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis.补充人参对运动耐力的影响作为心血管疾病管理的支持：一项系统评价和荟萃分析。
Antioxidants (Basel). 2024 Dec 29;14(1):32. doi: 10.3390/antiox14010032.
5
Ginsenoside Rb1 affects mitochondrial Ca transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1.人参皂苷Rb1通过与分泌型卷曲相关蛋白1（SFRP1）对接来调节Wnt信号通路，从而影响线粒体钙转运，并抑制脂肪沉积和纤维化，以治疗肩袖撕裂。
Mol Med. 2024 Dec 2;30(1):240. doi: 10.1186/s10020-024-01009-0.
6
Combining Metagenomics, Network Pharmacology and RNA-Seq Strategies to Reveal the Therapeutic Effects and Mechanisms of Qingchang Wenzhong Decoction on Inflammatory Bowel Disease in Mice.运用宏基因组学、网络药理学和 RNA-Seq 策略揭示清肠温中汤治疗小鼠炎症性肠病的疗效及作用机制。
Drug Des Devel Ther. 2024 Sep 24;18:4273-4289. doi: 10.2147/DDDT.S473688. eCollection 2024.
7
Investigating the Anti-Inflammatory, Analgesic, and Chondroprotective Effects of (Thunb.) Makino in Osteoarthritis: An In Vitro and In Vivo Study.研究（Thunb.）Makino 对骨关节炎的抗炎、镇痛和软骨保护作用：一项体外和体内研究。
Int J Mol Sci. 2024 Sep 4;25(17):9594. doi: 10.3390/ijms25179594.
帕金森病认知障碍：关注新兴药物治疗方法的最新概述。
Medicina (Kaunas). 2023 Oct 1;59(10):1756. doi: 10.3390/medicina59101756.
4
Age-related hearing loss and its potential drug candidates: a systematic review.年龄相关性听力损失及其潜在的候选药物：一项系统综述。
Chin Med. 2023 Sep 20;18(1):121. doi: 10.1186/s13020-023-00825-6.
5
Screening for Novel Inhibitors of Amyloid Beta Aggregation and Toxicity as Potential Drugs for Alzheimer's Disease.筛选新型β淀粉样蛋白聚集和毒性抑制剂作为治疗阿尔茨海默病的潜在药物。
Int J Mol Sci. 2023 Jul 11;24(14):11326. doi: 10.3390/ijms241411326.
6
Role of neuroinflammation in neurodegeneration development.神经炎症在神经退行性变发展中的作用。
Signal Transduct Target Ther. 2023 Jul 12;8(1):267. doi: 10.1038/s41392-023-01486-5.
7
Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats.人参皂苷Rb1抑制铁死亡以改善新生大鼠缺氧缺血性脑损伤。
Int Immunopharmacol. 2023 Aug;121:110503. doi: 10.1016/j.intimp.2023.110503. Epub 2023 Jun 24.
8
Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats.人参皂苷Rg1和Rb1对模拟微重力诱导的大鼠认知障碍的保护作用。
Front Pharmacol. 2023 Apr 24;14:1167398. doi: 10.3389/fphar.2023.1167398. eCollection 2023.
9
The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological, immunohistochemical, and biochemical study.人参皂苷Rb1对氯化铝诱导的阿尔茨海默病小鼠模型大脑皮质变化的神经保护作用：一项组织学、免疫组织化学和生物化学研究。
J Chem Neuroanat. 2023 Apr;129:102248. doi: 10.1016/j.jchemneu.2023.102248. Epub 2023 Feb 9.
10
Ginseng polysaccharides: Potential antitumor agents.人参多糖：潜在的抗肿瘤药物。
J Ginseng Res. 2023 Jan;47(1):9-22. doi: 10.1016/j.jgr.2022.07.002. Epub 2022 Jul 16.