Ling Gongxia, Zhang Min, Chen Chizhang, Wang Yan, Gao Qiqi, Li Jianshun, Yuan Hao, Jin Wenwen, Lin Wei, Yang Lingrong
Department of Pediatrics, The Second School of Medicine, Wenzhou Medical University, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Clinical Medicine, Pingyang County Traditional Chinese Medicine Hospital, Meizhou, Zhejiang, China.
Front Pharmacol. 2024 Jan 24;15:1280792. doi: 10.3389/fphar.2024.1280792. eCollection 2024.
Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)-a protopanaxadiol saponin and a typical ginseng component-exhibits anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-autophagy properties in the nervous system. Neurological disorders remain a leading cause of death and disability globally. GsRb1 effectively treats neurological disorders. To contribute novel insights to the understanding and treatment of neurological disorders, we present a comprehensive review of the pharmacokinetics, actions, mechanisms, and research development of GsRb1 in neurological disorders.
人参常用于传统中医治疗神经系统疾病。人参的主要活性成分是人参皂苷，根据其化学结构已被分为110多种类型。人参皂苷Rb1（GsRb1）——一种原人参二醇皂苷和典型的人参成分——在神经系统中具有抗炎、抗氧化、抗凋亡和抗自噬特性。神经系统疾病仍然是全球死亡和残疾的主要原因。GsRb1能有效治疗神经系统疾病。为了对神经系统疾病的理解和治疗提供新的见解，我们对GsRb1在神经系统疾病中的药代动力学、作用、机制和研究进展进行了全面综述。
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