Peng Zhi-Tian, Chao Ling-Hui, Wang Chao-Chao, Xia Hui, Liu Di-Fa, Wang Zhang-Wei, Zheng Jiao, Zhao Yun-Fang, Tu Peng-Fei, Li Jun
Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100029, China.
State Key Laboratory of Innovative Natural Medicine and Traditional Chinese Medicine Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd. Ganzhou 341000, China.
Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(3):579-583. doi: 10.19540/j.cnki.cjcmm.20191104.202.
This study is to investigate the chemical constituents from the whole plant Corydalis edulis. The chemical constituents were separated and purified by macroporous resin D101, silica gel, Sephadex LH-20, ODS, and semi-preparative HPLC. Their structures were determined by physicochemical properties and spectroscopic data. Four compounds were isolated from the dichloromethane and water extracts of the whole plant C. edulis, and identified as 6'-β-D-xylosylicariside B2(1),(3S,5R,6S,7E)-5,6-epoxy-3-hydroxy-7-megastigmen-9-one(2), loliolide(3), and 5,5'-dimethoxybiphenyl-2,2'-diol(4), respectively. Compound 1 is a new compound, of which the absolute configuration was established by electronic circular dichroism(ECD) calculations. Compound 4 is obtained from the plants of Papaveraceae family for the first time. Compounds 2 and 3 are firstly isolated from the Corydalis genus.
本研究旨在对紫堇全草的化学成分进行研究。采用大孔树脂D101、硅胶、葡聚糖凝胶LH-20、ODS及半制备高效液相色谱对化学成分进行分离纯化。通过理化性质和光谱数据确定其结构。从紫堇全草的二氯甲烷提取物和水提取物中分离得到4个化合物，分别鉴定为6'-β-D-木糖基紫堇苷B2(1)、(3S,5R,6S,7E)-5,6-环氧-3-羟基-7-大柱香波龙-9-酮(2)、黑麦草内酯(3)和5,5'-二甲氧基联苯-2,2'-二醇(4)。化合物1为新化合物，其绝对构型通过电子圆二色光谱(ECD)计算确定。化合物4首次从罂粟科植物中获得。化合物2和3首次从紫堇属植物中分离得到。
