Graduate Institute and Department of Pharmacology, National Taiwan University School of Medicine, No.1, Sec. 1, Ren-Ai Rd, 1150R, Taipei, Taiwan.
Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, No.1, Sec. 1, Ren-Ai Rd, 1150R, Taipei, Taiwan.
J Biomed Sci. 2020 Apr 2;27(1):48. doi: 10.1186/s12929-020-00647-w.
With the advances in deep sequencing-based transcriptome profiling technology, it is now known that human genome is transcribed more pervasively than previously thought. Up to 90% of the human DNA is transcribed, and a large proportion of the human genome is transcribed as long noncoding RNAs (lncRNAs), a heterogenous group of non-coding transcripts longer than 200 nucleotides. Emerging evidence suggests that lncRNAs are functional and contribute to the complex regulatory networks involved in cardiovascular development and diseases. In this article, we will review recent evidence on the roles of lncRNAs in the biological processes of cardiovascular development and disorders. The potential applications of lncRNAs as biomarkers and targets for therapeutics are also discussed.
随着基于深度测序的转录组分析技术的进步，现在已经知道人类基因组的转录比以前想象的更为普遍。高达 90%的人类 DNA 被转录，而大量的人类基因组则转录为长非编码 RNA（lncRNA），这是一组长度超过 200 个核苷酸的异质非编码转录本。新出现的证据表明，lncRNA 具有功能，并有助于涉及心血管发育和疾病的复杂调控网络。在本文中，我们将回顾 lncRNA 在心血管发育和紊乱的生物学过程中的作用的最新证据。还讨论了 lncRNA 作为生物标志物和治疗靶点的潜在应用。
