真菌耐药性的患病率及治疗挑战：植物在药物发现中的作用
Prevalence and Therapeutic Challenges of Fungal Drug Resistance: Role for Plants in Drug Discovery.
作者信息
Marquez Lewis, Quave Cassandra L
机构信息
Molecular and Systems Pharmacology, Emory University, Atlanta, GA 30322, USA.
Department of Dermatology and Center for the Study of Human Health, Emory University, Atlanta, GA 30322, USA.
出版信息
Antibiotics (Basel). 2020 Mar 31;9(4):150. doi: 10.3390/antibiotics9040150.
Abstract
Antimicrobial resistance is a global issue that threatens the effective practice of modern medicine and global health. The emergence of multidrug-resistant (MDR) fungal strains of and azole-resistant were highlighted in the Centers for Disease Control and Prevention's (CDC) 2019 report, . Conventional antifungals used to treat fungal infections are no longer as effective, leading to increased mortality. Compounding this issue, there are very few new antifungals currently in development. Plants from traditional medicine represent one possible research path to addressing the issue of MDR fungal pathogens. In this commentary piece, we discuss how medical ethnobotany-the study of how people use plants in medicine-can be used as a guide to identify plant species for the discovery and development of novel antifungal therapies.
摘要
抗菌耐药性是一个全球性问题，威胁着现代医学的有效实践和全球健康。美国疾病控制与预防中心（CDC）2019年的报告《》强调了多重耐药（MDR）真菌菌株和唑类耐药的出现。用于治疗真菌感染的传统抗真菌药物不再那么有效，导致死亡率上升。使这个问题更加复杂的是，目前正在研发的新型抗真菌药物很少。来自传统医学的植物代表了应对多重耐药真菌病原体问题的一条可能的研究途径。在这篇评论文章中，我们讨论了医学民族植物学——研究人们如何在医学中使用植物——如何能够作为一种指导，来识别用于发现和开发新型抗真菌疗法的植物物种。
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