Chiticaru Elena Alina, Ioniță Mariana
Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, Gh Polizu 1-7, 011061, Bucharest, Romania.
Advanced Polymer Materials Group, National University of Science and Technology Politehnica Bucharest, Gh Polizu 1-7, 011061, Bucharest, Romania.
Mater Today Bio. 2024 Nov 14;29:101341. doi: 10.1016/j.mtbio.2024.101341. eCollection 2024 Dec.
Bioprinting and bioinks are two of the game changers in bone tissue engineering. This review presents different bioprinting technologies including extrusion-based, inkjet-based, laser-assisted, light-based, and hybrid technologies with their own strengths and weaknesses. This review will aid researchers in the selection and assessment of the bioink; the discussion ranges from commercially available bioinks to custom lab-made formulations mainly based on natural polymers, such as agarose, alginate, gelatin, collagen, and chitosan, designed for bone tissue engineering. The review is centered on technological advancements and increasing clinical demand within the rapidly growing bioprinting market. From this point of view, 4D, 5D, and 6D printing technologies promise a future where unprecedented levels of innovation will be involved in fabrication processes leading to more dynamic multifunctionalities of bioprinted constructs. Further advances in bioprinting technology, such as hybrid bioprinting methods are covered, with the promise to meet personalized medicine goals while advancing patient outcomes for bone tissues engineering applications.
生物打印和生物墨水是骨组织工程领域的两大变革性技术。本综述介绍了不同的生物打印技术，包括基于挤出的、基于喷墨的、激光辅助的、基于光的以及混合技术，同时阐述了它们各自的优缺点。本综述将有助于研究人员选择和评估生物墨水；讨论范围从市售生物墨水到主要基于天然聚合物（如琼脂糖、海藻酸盐、明胶、胶原蛋白和壳聚糖）的定制实验室配方，这些配方是为骨组织工程设计的。本综述围绕快速发展的生物打印市场中的技术进步和不断增长的临床需求展开。从这一角度来看，4D、5D和6D打印技术预示着一个未来，即在制造过程中将涉及前所未有的创新水平，从而使生物打印构建体具有更多动态多功能性。文中还介绍了生物打印技术的进一步进展，如混合生物打印方法，有望在推进骨组织工程应用的患者治疗效果的同时实现个性化医疗目标。
