Pulmonary Operative Unit, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Romagna Health Company, 47121 Forlì, Italy.
Head & Neck Department, Ear Nose Throat (ENT) Unit, Santa Maria delle Croci Hospital, Romagna Health Company, 48121 Ravenna, Italy.
Int J Environ Res Public Health. 2020 Mar 20;17(6):2058. doi: 10.3390/ijerph17062058.
The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep-wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.
A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.
96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits' measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.
上气道的解剖可塌陷性、神经肌肉张力和功能、睡眠-觉醒和通气控制不稳定以及觉醒阈值相互作用并促成了不同类型阻塞性睡眠呼吸暂停（OSA）的某些病理生理特征。定性表型分析模型使我们能够描述 OSA 患者的不同病理生理特征。
进行了叙述性综述，以分析现有文献证据，目的是生成定性表型分析模型，以描述 OSA 患者的病理生理特征。
在 3829 篇摘要中，有 96 篇被选为全文审查。OSA 的定性表型分析模型：通过临床 PSG、OSA 严重程度分级以及持续气道正压通气（CPAP）的治疗水平，可以得出有关 OSA 定性病理生理特征的测量数据，并在文中报告。这种方法可以通过在常规临床环境中广泛使用的方法进行定性表型分析，这对于睡眠专家、手术治疗决策和定制 OSA 多模式治疗特别有意义。
