Rosero Ilem D, Ramírez-Vélez Robinson, Martínez-Velilla Nicolas, Cedeño-Veloz Bernardo Abel, Morilla Idoia, Izquierdo Mikel
Department of Health Sciences, Public University of Navarra, Navarrabiomed-Biomedical Research Centre, IDISNA-Navarra's Health Research Institute. C/irunlarrea 3, Complejo Hospitalario de Navarra, 31008 Pamplona, Navarra 31008, Spain.
Biomedical Research Networking Centre on Frailty and Healthy Ageing, CIBERFES, 28029 Madrid, Spain.
J Clin Med. 2020 Mar 21;9(3):862. doi: 10.3390/jcm9030862.
Clinical intervention studies support the efficacy and safety of exercise programs as a treatment modality for non-small-cell lung cancer (NSCLC) during adjuvant/palliative treatment, but the effectiveness of real-world oncogeriatric services is yet to be established. We aimed to examine the effects of a 10-week structured and individualized multicomponent exercise program on physical/cognitive functioning and mental wellness in elderly patients with NSCLC under adjuvant therapy or palliative treatment. A non-randomized, opportunistic control, longitudinal-design trial was conducted on 26 patients with NSCLC stage I-IV. Of 34 eligible participants, 21 were allocated into two groups: (i) control group ( = 7) received usual medical care; and (ii) intervention group ( =19) received multicomponent program sessions, including endurance, strength, balance, coordination and stretching exercises. Tests included the Short Physical Performance Battery (SPPB), 5-m habitual Gait Velocity Test (GVT), Timed Up & Go Test (TUG), 6-Min Walk Test (6MWT), independence of activities in daily living (IADL), muscular performance, cognitive function, and quality of life, which were measured at baseline and after 10 weeks of the program. Results revealed a significant group×time interaction for SPPB ( = 0.004), 5-m GVT ( = 0.036), TUG ( = 0.007), and muscular performance (chest and leg power; < 0.001). Similarly, significant changes were observed between groups for cognitive functioning ( = 0.021) and quality of life for EUROQoL 5D ( = 0.006). Our findings confirm that a multicomponent exercise program improves measures of physical/cognitive functioning and quality of life in the elderly with NSCLC under adjuvant therapy or palliative treatment. This is an interesting and important study that adds to our current body of knowledge on the safety of exercise interventions, especially in the elderly with solid tumors.
临床干预研究支持运动计划作为非小细胞肺癌（NSCLC）辅助/姑息治疗的一种治疗方式的有效性和安全性，但现实世界中肿瘤老年医学服务的有效性尚未得到证实。我们旨在研究一项为期10周的结构化、个性化多组分运动计划对接受辅助治疗或姑息治疗的老年NSCLC患者身体/认知功能和心理健康的影响。对26例I-IV期NSCLC患者进行了一项非随机、机会性对照、纵向设计试验。在34名符合条件的参与者中，21人被分为两组：（i）对照组（=7）接受常规医疗护理；（ii）干预组（=19）接受多组分计划课程，包括耐力、力量、平衡、协调和伸展运动。测试包括简短体能表现量表（SPPB）、5米习惯性步态速度测试（GVT）、定时起立行走测试（TUG）、6分钟步行测试（6MWT）、日常生活活动独立性（IADL）、肌肉性能、认知功能和生活质量，在基线时和计划进行10周后进行测量。结果显示，SPPB（=0.004）、5米GVT（=0.036）、TUG（=0.007）和肌肉性能（胸部和腿部力量；<0.001）存在显著的组×时间交互作用。同样，两组之间在认知功能（=0.021）和欧洲生活质量五维度量表（EQ-5D）生活质量（=0.006）方面也观察到显著变化。我们的研究结果证实，多组分运动计划可改善接受辅助治疗或姑息治疗的老年NSCLC患者的身体/认知功能指标和生活质量。这是一项有趣且重要的研究，增加了我们目前关于运动干预安全性的知识体系，尤其是在患有实体瘤的老年人中。
