National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.
Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.
Contact Dermatitis. 2020 Oct;83(4):251-270. doi: 10.1111/cod.13550. Epub 2020 Jun 16.
Naturally derived cosmetic product ingredients of both plant and animal origin are being included increasingly in product formulations in order to cater to consumer preferences. They may be an overlooked cause of reactions to cosmetic products in some patients with dermatitis.
To identify naturally derived cosmetic product ingredients with allergenic potential (type I and type IV) and propose a cosmetic screening test series.
The study was conducted in two steps. The first step was a market survey using a nonprofit application helping consumers avoid problematic substances in cosmetic products. The application contained 10 067 cosmetic products that were label checked for naturally derived cosmetic product ingredients. The second step was a literature search to examine how frequently the naturally derived ingredients were described and related to allergic reactions in cosmetics or other topically administered products.
We identified 121 different naturally derived cosmetic product ingredients that were included in at least 30 cosmetic products. In total, 22 ingredients were selected for a screening test series.
We propose a supplemental patch test and a prick test screening series with naturally derived cosmetic product ingredients for patients with skin reactions to cosmetic products, aiming to identify a cause in more patients than is currently possible.
为了迎合消费者的喜好，越来越多的植物和动物源性天然化妆品成分被添加到产品配方中。在一些患有皮炎的患者中，这些成分可能是导致他们对化妆品产生不良反应的一个被忽视的原因。
确定具有潜在致敏性（I 型和 IV 型）的天然化妆品成分，并提出一个化妆品筛选测试系列。
该研究分两步进行。第一步是使用一个非营利性应用程序进行市场调查，该应用程序帮助消费者避免化妆品中的有害物质。该应用程序包含了 10067 种化妆品，对其标签上的天然化妆品成分进行了检查。第二步是文献检索，以检查天然成分在化妆品或其他局部应用产品中被描述和与过敏反应相关的频率。
我们确定了 121 种不同的天然化妆品成分，这些成分至少包含在 30 种化妆品中。共有 22 种成分被选为筛选测试系列。
我们针对对化妆品有皮肤反应的患者提出了一个补充斑贴试验和皮内试验筛选系列，使用天然化妆品成分，旨在比目前可能的情况更能确定病因。
