2D magnetic titanium carbide MXene for cancer theranostics.

Fast progress of two-dimensional (2D) materials has catalyzed the emergence of diverse new 2D nanosystems for versatile applications, among which 2D MXenes have attracted broad interest but their single functionality significantly restricts their extensive applications, especially in nanomedicine. Herein we report, for the first time, on the construction of superparamagnetic 2D TiC MXenes for highly efficient cancer theranostics, which is based on the surface chemistry of specific MXenes for the in situ growth of superparamagnetic FeO nanocrystals onto the surface of TiC MXenes. These magnetic TiC-IONPs MXene composites exhibit a high T relaxivity of 394.2 mM s and efficient contrast-enhanced magnetic resonance imaging of tumors, providing the potential for therapeutic guidance. Importantly, these superparamagnetic MXenes have shown high photothermal conversion efficiency (48.6%) to guarantee the efficient photothermal killing of cancer cells and ablation of tumor tissues, which has been systematically demonstrated both in vitro and in vivo. The high biocompatibility of these elaborately designed magnetic TiC-based MXene composites guarantees their further potential clinical translation. This report paves a new way for the functionalization of MXene-based 2D nanosheets for broadening their novel applications based on the unique surface chemistry of MXenes, especially in theranostic nanomedicine.