College of Chemical Engineering, Nanjing Forestry University, Jiangsu Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Nanjing 210037, P. R. China.
J Mater Chem B. 2019 Jan 14;7(2):314-323. doi: 10.1039/c8tb02947d. Epub 2018 Dec 14.
Recently, reactive oxygen species (ROS)-induced apoptosis has been widely studied by researchers through various means. Among them, the singlet oxygen produced by the Fenton reaction is particularly effective in killing tumor cells. Although photodynamic therapy (PDT) takes advantage of the spatial-temporal control of ROS production, the design of the Fenton reaction in an ingenious way is still a question worth exploring. Herein, we have designed and prepared a succinic peroxide-filled Fenton reaction activable Pt/FeO@SP-PLGA lipo-polymersome that displays ROS mediated chemodynamic therapy (CDT). The therapeutic element, ˙OH, is generated under NIR irradiation/tumor acidic pH environment through engineering the reaction between succinic peroxide (SP) and iron oxide. Instead of using single endogenous HO or even encapsulation, the conjugation with SP in the Pt/FeO@SP-PLGA lipo-polymersome provides a more stable, high-yielding peroxygen source. The results also showed that after the addition of cisplatin, the amount of ROS production increased significantly. The proof-of-concept design of the Fenton reaction activable Pt/FeO@SP-PLGA lipo-polymersome with enhanced ROS-generation characteristics provides a general approach to afford potent ROS-mediated cancer therapy.
最近，研究人员通过各种手段广泛研究了活性氧（ROS）诱导的细胞凋亡。其中，芬顿反应产生的单线态氧在杀伤肿瘤细胞方面特别有效。虽然光动力疗法（PDT）利用了 ROS 产生的时空控制，但巧妙地设计芬顿反应仍然是一个值得探索的问题。在此，我们设计并制备了一种填充过氧琥珀酸的芬顿反应激活的 Pt/FeO@SP-PLGA 脂质体聚合物，该聚合物具有 ROS 介导的化学动力学治疗（CDT）作用。治疗元素˙OH 通过工程化过氧琥珀酸（SP）与氧化铁之间的反应，在近红外照射/肿瘤酸性 pH 环境下生成。Pt/FeO@SP-PLGA 脂质体聚合物与 SP 的结合取代了使用单一内源性 HO 甚至封装，提供了更稳定、高产的过氧源。结果还表明，加入顺铂后，ROS 产生量显著增加。具有增强 ROS 生成特性的芬顿反应激活的 Pt/FeO@SP-PLGA 脂质体聚合物的概念验证设计为提供了一种有效的 ROS 介导的癌症治疗方法。
