Habte Mezgebu Legesse, Melka Daniel Seifu, Degef Maria, Menon M K C, Yifter Helen, Feyisa Teka Obsa
Department of Biochemistry, School of Medicine, College of Health and Medical Sciences, Harmaya University, Harar, Ethiopia.
Department of Medical Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Diabetes Metab Syndr Obes. 2020 Mar 18;13:763-773. doi: 10.2147/DMSO.S234382. eCollection 2020.
Diabetes mellitus (DM) is an epidemic disease affecting millions worldwide; the majority being type 2 diabetes mellitus (T2DM). Diabetes mellitus has been shown to be an important risk factor for the development of a variety of cardiovascular diseases, which are becoming common in Ethiopia. Consequently, risk-reducing statin therapy is recommended for nearly all patients with T2DM at 40 years of age or older regardless of cholesterol level. However, some controversies exist regarding its safety.
The aim of this study was to assess and compare the levels of lipid profile, liver enzymes, creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) among T2DM patients on statin therapy.
A hospital-based cross-sectional study was conducted on a total of 100 T2DM patients. The study participants were divided into four groups consisting of equal numbers of participants (n = 25). Group I, II, and III were T2DM patients who were on statin therapy for 14 days-6 months, 6-18 months and ˃18 months, respectively. Group IV consisted of T2DM patients who were not on statin therapy. Convenient sampling technique was implemented till the required number had been achieved. Sociodemographic data was collected by using a standardized questionnaire. Fasting blood was collected and lipid profile, liver enzymes, CK-MB, LDH and fasting blood sugar were analyzed. Data was entered using epi-data and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 20.00. A value < 0.05 was considered statistically significant.
The mean values of total cholesterol and TAG were significantly lower among group III as compared to group I (values = 0.019 & 0.01). Similarly, LDL-c was significantly lower among group III as compared to group I ( = 0.022) and group IV ( = 0.027). Serum liver enzymes, CK-MB and LDH were not significantly different among the study groups ( > 0.05). The mean values of alanine aminotransferase (ALT) and AST were found within normal range while mean ALP was higher in all study groups. Fasting blood glucose value was not significantly different among the study groups, but higher than normal cut-off value in all groups.
Statin therapy taken for a longer time has an effect in lowering total cholesterol, LDL- c and TAG in T2DM patients. Statin therapy has not brought significant change on CK-MB, LDH, liver enzymes and other parameters among T2DM patients.
糖尿病（DM）是一种在全球影响数百万人的流行病；其中大多数为2型糖尿病（T2DM）。糖尿病已被证明是多种心血管疾病发生的重要危险因素，这些疾病在埃塞俄比亚正变得日益普遍。因此，无论胆固醇水平如何，几乎所有40岁及以上的T2DM患者都建议接受降低风险的他汀类药物治疗。然而，关于其安全性存在一些争议。
本研究的目的是评估和比较接受他汀类药物治疗的T2DM患者的血脂谱、肝酶、肌酸激酶-MB（CK-MB）和乳酸脱氢酶（LDH）水平。
对总共100名T2DM患者进行了一项基于医院的横断面研究。研究参与者被分为四组，每组人数相等（n = 25）。第一组、第二组和第三组分别是接受他汀类药物治疗14天至6个月、6至18个月和超过18个月的T2DM患者。第四组由未接受他汀类药物治疗的T2DM患者组成。采用方便抽样技术，直至达到所需数量。通过使用标准化问卷收集社会人口统计学数据。采集空腹血并分析血脂谱、肝酶、CK-MB、LDH和空腹血糖。数据使用Epi-Data录入，并使用SPSS V. 20.00进行单因素方差分析，随后进行Tukey事后多重比较检验。P值< 0.05被认为具有统计学意义。
与第一组相比，第三组的总胆固醇和甘油三酯平均值显著降低（P值 = 0.019和0.01）。同样，与第一组（P = 0.022）和第四组（P = 0.027）相比，第三组的低密度脂蛋白胆固醇显著降低。研究组之间的血清肝酶、CK-MB和LDH无显著差异（P > 0.05）。丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶的平均值在正常范围内，而所有研究组的碱性磷酸酶平均值较高。研究组之间的空腹血糖值无显著差异，但所有组均高于正常临界值。
较长时间服用他汀类药物对降低T2DM患者的总胆固醇、低密度脂蛋白胆固醇和甘油三酯有作用。他汀类药物治疗未使T2DM患者的CK-MB、LDH、肝酶和其他参数发生显著变化。
