Rodrigues Lucas S, da Silva Nali Luiz H, Leal Cibele O D, Sabino Ester C, Lacerda Eliana M, Kingdon Caroline C, Nacul Luis, Romano Camila M
1Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Rua Dr. Enéas de Carvalho Aguiar, 470, São Paulo, SP 05403-000 Brazil.
2Pós-Graduação em Ciências da Saúde, Universidade Santo Amaro, São Paulo, Brazil.
Auto Immun Highlights. 2019 Nov 15;10(1):12. doi: 10.1186/s13317-019-0122-8. eCollection 2019 Dec.
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases.
Here the expression of Endogenous retroviruses K and W (HERV-K and HERV-W) was determined in blood from moderately and severely affected ME/CFS patients through real time PCR.
HERV-K was overexpressed only in moderately affected individuals but HERV-W showed no difference.
This is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention.
慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）是一种使人衰弱的慢性疾病，严重影响生活质量。CFS/ME的发病机制是多因素的，据信免疫、代谢和环境因素都起作用。有充分的文献记载，来自不同家族的人类内源性逆转录病毒（HERV）在自身免疫性疾病和神经系统疾病中的活性增加，这使得这些元素成为此类疾病生物标志物甚至触发因素的良好候选者。
在此，通过实时PCR测定中度和重度受影响的ME/CFS患者血液中内源性逆转录病毒K和W（HERV-K和HERV-W）的表达。
HERV-K仅在中度受影响个体中过度表达，但HERV-W无差异。
这是关于HERV-K在中度ME/CFS中差异表达的首次报告。尽管HERV与ME/CFS之间的关系尚未得到证实，但这一现象的观察值得进一步关注。
