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无干扰素和基于干扰素治疗对 HCV 感染期间血液髓样树突状细胞、单核细胞、Slan-DC 和活化 T 淋巴细胞动力学的影响。

Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.

机构信息

Department of Public Health and Infectious Disease, Sapienza University of Rome, Italy.

S.M. Goretti Hospital, Latina, Italy.

出版信息

J Immunol Res. 2020 Mar 16;2020:2781350. doi: 10.1155/2020/2781350. eCollection 2020.

DOI:10.1155/2020/2781350
PMID:32258171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7102477/
Abstract

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.

摘要

慢性丙型肝炎病毒感染会导致先天免疫激活，这是丙型肝炎纤维化的一个关键组成部分。过去，由于干扰素具有抗病毒和免疫调节特性，基于 IFN 的治疗方案无法充分评估 HCV 清除对免疫细胞的影响。最近直接作用抗病毒（DAA）治疗的发展与高持续病毒学应答率相关，使我们能够更准确地分析 HCV 清除后免疫的变化。我们研究了在丙型肝炎病毒感染中，无干扰素和基于干扰素的方案期间血液髓样树突状细胞、单核细胞、slan-DC 和 T 淋巴细胞的动态变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/6f7e88ec3a07/JIR2020-2781350.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/6a823ce11092/JIR2020-2781350.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/ae246620fdf1/JIR2020-2781350.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/d0e9dc4f730a/JIR2020-2781350.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/bfbddf843edb/JIR2020-2781350.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/5072a823c991/JIR2020-2781350.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/6f7e88ec3a07/JIR2020-2781350.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/6a823ce11092/JIR2020-2781350.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/ae246620fdf1/JIR2020-2781350.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/d0e9dc4f730a/JIR2020-2781350.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/bfbddf843edb/JIR2020-2781350.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/5072a823c991/JIR2020-2781350.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a84b/7102477/6f7e88ec3a07/JIR2020-2781350.006.jpg

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