Kim Yoon Kyung, Chen Esther Y, Liu Wendy F
Department of Biomedical Engineering, University of California Irvine, 2412 Engineering Hall, Irvine, CA 92697, USA.
J Mater Chem B. 2016 Mar 7;4(9):1600-1609. doi: 10.1039/c5tb01605c. Epub 2015 Sep 25.
The material-induced foreign body response is a major challenge for implanted medical devices. This review highlights recent developments in biomimetic approaches to create biomaterials that mitigate the host response to biomaterials. Specifically, we will describe strategies in which biomaterials are decorated with endogenously expressed biomolecules that naturally modulate the function of immune cells. These include molecules that directly bind to and interact with immune cells, as well as molecules that control complement activation or thrombosis and indirectly modulate immune cell function. We provide perspective on how these approaches may impact the design of materials for medical devices and tissue engineering.
材料引起的异物反应是植入式医疗设备面临的一项重大挑战。本综述重点介绍了仿生方法的最新进展，这些方法用于制造能够减轻宿主对生物材料反应的生物材料。具体而言，我们将描述一些策略，即通过内源性表达的生物分子修饰生物材料，这些生物分子可自然调节免疫细胞的功能。这些分子包括直接与免疫细胞结合并相互作用的分子，以及控制补体激活或血栓形成并间接调节免疫细胞功能的分子。我们就这些方法如何影响医疗设备和组织工程材料的设计提供了观点。
