Shimanovich U, Gedanken A
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
J Mater Chem B. 2016 Feb 7;4(5):824-833. doi: 10.1039/c5tb01527h. Epub 2016 Jan 7.
This review focuses on the development of nanoparticle systems that enables to enhance and restore the antibiotic activity for drug-resistant organisms. New and more aggressive antibiotic resistant bacteria and parasites calls for the development of new therapeutic strategies to overcome the inefficiency of conventional antibiotics and bypass treatment limitations related to these pathologies. Nanostructured biomaterials, nanoparticles in particular, have unique physicochemical properties such as ultra-small and controllable size, large surface area to mass ratio, high reactivity, and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. Here the current progress and challenges in synthesizing nanoparticle platforms for restoring activity of various antimicrobial drugs are reviewed with an emphasis on antibiotics. We also call attention to the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases.
本综述聚焦于纳米颗粒系统的发展，该系统能够增强和恢复针对耐药生物体的抗生素活性。新型且更具侵袭性的抗生素耐药细菌和寄生虫促使人们开发新的治疗策略，以克服传统抗生素的低效性，并绕过与这些病症相关的治疗局限性。纳米结构生物材料，尤其是纳米颗粒，具有独特的物理化学性质，如超小且可控的尺寸、大的表面积与质量比、高反应活性以及可功能化的结构。这些性质可用于促进抗菌药物的给药，从而克服传统抗菌治疗中的一些局限性。在此，我们综述了用于恢复各种抗菌药物活性的纳米颗粒平台合成方面的当前进展和挑战，重点是抗生素。我们还提请注意，在开发用于治疗微生物疾病的纳米技术方面，纳米工程师和微生物学家需要联合他们的共同兴趣。
