Guo Liang, Liu Weimin, Niu Guangle, Zhang Panpan, Zheng Xiuli, Jia Qingyan, Zhang Hongyan, Ge Jiechao, Wang Pengfei
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
J Mater Chem B. 2017 Apr 21;5(15):2832-2839. doi: 10.1039/c7tb00498b. Epub 2017 Mar 31.
Synthesis of photothermal agents with absorption in the near-infrared (NIR) region and featuring excellent photostability, high photothermal conversion efficiency, and good biocompatibility is necessary for the application of photothermal therapy (PTT). In this work, a low band gap thiophene-benzene-diketopyrrolopyrrole (TBD)-based polymer was synthesized and used to fabricate TBD polymer nanoparticles (TBDPNPs) through a one-step nanoprecipitation method. The obtained near-infrared-absorbing TBDPNPs presented good water dispersibility, high photothermal stability, and low toxicity. Significantly, the TBDPNPs exhibited an ultrahigh photothermal conversion efficiency of approximately 68.1% under 671 nm laser irradiation. In addition, photoacoustic (PA) imaging, with high spatial resolution and deep tissue penetration, showed that the TBDPNPs targeted tumor sites through the enhanced permeability and retention effect. Therefore, the robust TBDPNPs with a photothermal conversion efficiency of 68.1% can serve as an excellent therapeutic agent for PA-imaging-guided PTT.
合成在近红外（NIR）区域具有吸收能力、具备优异光稳定性、高光热转换效率和良好生物相容性的光热剂对于光热疗法（PTT）的应用至关重要。在这项工作中，合成了一种基于低带隙噻吩-苯-二酮吡咯并吡咯（TBD）的聚合物，并通过一步纳米沉淀法将其用于制备TBD聚合物纳米颗粒（TBDPNPs）。所获得的吸收近红外光的TBDPNPs表现出良好的水分散性、高光热稳定性和低毒性。值得注意的是，在671 nm激光照射下，TBDPNPs表现出约68.1%的超高光热转换效率。此外，具有高空间分辨率和深层组织穿透能力的光声（PA）成像表明，TBDPNPs通过增强的渗透和滞留效应靶向肿瘤部位。因此，光热转换效率为68.1%的强大TBDPNPs可作为PA成像引导的PTT的优异治疗剂。
