Zhu Yingnan, Zhang Jiamin, Song Jiayin, Yang Jing, Xu Tong, Pan Chao, Zhang Lei
Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
J Mater Chem B. 2017 Nov 21;5(43):8451-8458. doi: 10.1039/c7tb02477k. Epub 2017 Oct 30.
Preventing bacterial contamination, treating wound infections and promoting wound healing have been major challenges in wound care management. In this work, a novel wound dressing based on a zwitterionic polycarboxybetaine (PCB) hydrogel and antibacterial silver nanoparticles (AgNPs) was developed via a one-step method for the efficient treatment of infected wounds. The PCB-AgNP hydrogel exhibits effective antibacterial ability against both Gram positive bacteria (Saphylococcus aureus) and Gram negative bacteria (Escherichia coli). Furthermore, in a murine model, the PCB-AgNP hydrogel is found to efficiently treat S. aureus infection and accelerate cutaneous wound healing. After a two-week healing process, histological tests indicate that it can promote the reconstruction of intact epidermis, which is much faster than those treated with a commercial wound dressing (Duoderm® film). This new bifunctional wound dressing provides new opportunities for highly efficient skin wound care and management.
预防细菌污染、治疗伤口感染和促进伤口愈合一直是伤口护理管理中的主要挑战。在这项工作中，通过一步法开发了一种基于两性离子聚羧基甜菜碱（PCB）水凝胶和抗菌银纳米颗粒（AgNPs）的新型伤口敷料，用于有效治疗感染伤口。PCB-AgNP水凝胶对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）均表现出有效的抗菌能力。此外，在小鼠模型中，发现PCB-AgNP水凝胶能有效治疗金黄色葡萄球菌感染并加速皮肤伤口愈合。经过两周的愈合过程，组织学测试表明它可以促进完整表皮的重建，这比使用商用伤口敷料（Duoderm®薄膜）治疗的速度要快得多。这种新型双功能伤口敷料为高效的皮肤伤口护理和管理提供了新的机会。
