Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University, Shenzhen, Guangdong, China.
J Hum Hypertens. 2021 Mar;35(3):274-279. doi: 10.1038/s41371-020-0333-5. Epub 2020 Apr 7.
Brachial pulse pressure (PP) was used as a measure of arterial stiffness, and we investigated whether PP was associated with all-cause and cause-specific mortality in a rural Chinese population. A total of 13,223 participants were enrolled in the Rural Chinese Cohort Study during 2007-2008 and followed up in 2013-2014. Data were collected by questionnaire interview, anthropometric, and laboratory measurements. A multivariate Cox proportional-hazard model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of PP (increased by 1 standard deviation) for all-cause and cause-specific mortality. Subgroup analyses were conducted by sex and age. During a mean follow-up of 5.96 years, the all-cause mortality was 78.61/10000 person-years. The association of PP with all-cause and other causes of mortality was significant, and the adjusted HRs (95% CIs) were 1.16 (1.06-1.28), and 1.18 (1.00-1.40), respectively. On subgroup analyses, PP was positively associated with all-cause and cardiovascular disease (CVD) in participants <65 years or males and positively associated with other causes of mortality in males. The risk of all-cause and other causes of mortality increased with increasing PP in a rural Chinese population. Higher PP may increase the risk of all-cause and CVD mortality for males and people <65 years as well as the risk of other causes of mortality for males in rural Chinese people.
肱动脉脉搏压（PP）被用作动脉僵硬的指标，我们研究了在农村中国人群中，PP 是否与全因和特定原因死亡率相关。共有 13223 名参与者在 2007-2008 年期间被纳入农村中国队列研究，并在 2013-2014 年进行了随访。数据通过问卷调查、人体测量和实验室测量收集。使用多变量 Cox 比例风险模型来估计 PP（增加 1 个标准差）与全因和特定原因死亡率的风险比（HR）和 95%置信区间（CI）。进行了按性别和年龄的亚组分析。在平均 5.96 年的随访期间，全因死亡率为 78.61/10000 人年。PP 与全因和其他原因死亡率的相关性具有统计学意义，调整后的 HR（95%CI）分别为 1.16（1.06-1.28）和 1.18（1.00-1.40）。在亚组分析中，PP 与<65 岁或男性的全因和心血管疾病（CVD）死亡率呈正相关，与男性的其他死因死亡率呈正相关。在农村中国人群中，PP 越高，全因和其他死因死亡率的风险越高。较高的 PP 可能会增加男性和<65 岁人群的全因和 CVD 死亡率风险，以及男性的其他死因死亡率风险。
