Park Inkyung, Oh Sungtaek, Lillehoj Erik P, Lillehoj Hyun S
Animal Bioscience and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD, United States.
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Front Vet Sci. 2020 Mar 24;7:157. doi: 10.3389/fvets.2020.00157. eCollection 2020.
Magnolia bark extract administered as a dietary supplement to poultry confers a performance and health benefit, but the mechanisms are unknown. Here, a metabolomics approach was used to identify changes in intestinal metabolite levels in chickens fed an unsupplemented diet or a diet supplemented with magnolia bark extract. Total body weight gains of chickens fed magnolia bark-supplemented diets were increased 2% (from 861 to 878 g/chicken), compared with chickens fed an unsupplemented diet. Compared with unsupplemented controls, the levels of 278 intestinal biochemicals (metabolites) were altered (165 increased, 113 decreased) in chickens given the magnolia-supplemented diet. Data for biochemicals of intestinal contents of chickens fed the unsupplemented diet clustered on the left side of the PCA score plot, while those of the magnolia-supplemented diet were separated and clustered on the right side. The biochemicals included changes in the levels of amino acids, fatty acids, peptides, and nucleosides, which provided a distinctive biochemical signature unique to the magnolia-supplemented group, compared with the unsupplemented group. These results provide the foundation for future studies to identify naturally-produced biochemicals that might be used to improve poultry growth performance.
作为膳食补充剂给予家禽的厚朴树皮提取物具有提高生产性能和有益健康的作用，但其作用机制尚不清楚。在此，采用代谢组学方法来确定饲喂未添加或添加厚朴树皮提取物日粮的鸡肠道代谢物水平的变化。与饲喂未添加日粮的鸡相比，饲喂添加厚朴树皮日粮的鸡总体重增加了2%（从861克/只增加到878克/只）。与未添加的对照组相比，饲喂添加厚朴日粮的鸡中有278种肠道生化物质（代谢物）的水平发生了改变（165种增加，113种减少）。饲喂未添加日粮的鸡肠道内容物生化物质的数据聚集在主成分分析（PCA）得分图的左侧，而饲喂添加厚朴日粮的鸡的数据则分开并聚集在右侧。这些生化物质包括氨基酸、脂肪酸、肽和核苷水平的变化，与未添加组相比，这些变化为添加厚朴组提供了独特的生化特征。这些结果为未来研究确定可能用于改善家禽生长性能的天然产生的生化物质奠定了基础。
