新的小胶质细胞。
New Microglia on the Block.
机构信息
Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea.
Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University, College of Medicine, Seoul 03080, South Korea; SNU Dementia Research Center, Seoul National University, College of Medicine, Seoul 03080, South Korea.
出版信息
Cell Metab. 2020 Apr 7;31(4):664-666. doi: 10.1016/j.cmet.2020.03.015.
Microglia exhibit differing functions and phenotypes depending on life stage and the context of health or disease. Recently, in Nature Neuroscience, Marschallinger et al. (2020) described a new state of microglia, namely "lipid-droplet-accumulating microglia" (LDAM), that contributes to neuronal inflammation and age-related neurodegeneration.
小胶质细胞根据生命阶段以及健康或疾病的背景表现出不同的功能和表型。最近，在《自然神经科学》杂志上，Marschallinger 等人（2020 年）描述了小胶质细胞的一种新状态，即“脂滴积累小胶质细胞”（LDAM），它有助于神经元炎症和与年龄相关的神经退行性变。
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