Alam Mohammad Wajih, Vedaei Seyed Shahim, Wahid Khan A
Department of Electrical and Computer Engineering, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
Cancers (Basel). 2020 Apr 6;12(4):890. doi: 10.3390/cancers12040890.
Wireless capsule endoscopy (WCE) has been widely used in gastrointestinal (GI) diagnosis that allows the physicians to examine the interior wall of the human GI tract through a pain-free procedure. However, there are still several limitations of the technology, which limits its functionality, ultimately limiting its wide acceptance. Its counterpart, the wired endoscopic system is a painful procedure that demotivates patients from going through the procedure, and adversely affects early diagnosis. Furthermore, the current generation of capsules is unable to automate the detection of abnormality. As a result, physicians are required to spend longer hours to examine each image from the endoscopic capsule for abnormalities, which makes this technology tiresome and error-prone. Early detection of cancer is important to improve the survival rate in patients with colorectal cancer. Hence, a fluorescence-imaging-based endoscopic capsule that automates the detection process of colorectal cancer was designed and developed in our lab. The proof of concept of this endoscopic capsule was tested on porcine intestine and liquid phantom. The proposed WCE system offers great possibilities for future applicability in selective and specific detection of other fluorescently labelled cancers.
无线胶囊内镜（WCE）已广泛应用于胃肠道（GI）诊断，使医生能够通过无痛程序检查人体胃肠道内壁。然而，该技术仍存在一些局限性，这限制了其功能，最终限制了其广泛应用。其对应的有线内镜系统是一种痛苦的程序，会使患者不愿接受该检查，进而对早期诊断产生不利影响。此外，当前一代的胶囊无法自动检测异常。因此，医生需要花费更长时间检查来自内镜胶囊的每张图像以查找异常，这使得该技术既繁琐又容易出错。早期发现癌症对于提高结直肠癌患者的生存率很重要。因此，我们实验室设计并开发了一种基于荧光成像的内镜胶囊，可自动检测结直肠癌。该内镜胶囊的概念验证在猪肠道和液体模型上进行了测试。所提出的无线胶囊内镜系统为未来在选择性和特异性检测其他荧光标记癌症方面的应用提供了巨大可能性。
