Center for Molecular and Translational Medicine, Georgia State University, Atlanta, GA, USA.
Exp Mol Med. 2020 Apr;52(4):548-555. doi: 10.1038/s12276-020-0415-z. Epub 2020 Apr 8.
Aging is a universal process that renders individuals vulnerable to many diseases. Although this process is irreversible, dietary modulation and caloric restriction are often considered to have antiaging effects. Dietary modulation can increase and maintain circulating ketone bodies, especially β-hydroxybutyrate (β-HB), which is one of the most abundant ketone bodies in human circulation. Increased β-HB has been reported to prevent or improve the symptoms of various age-associated diseases. Indeed, numerous studies have reported that a ketogenic diet or ketone ester administration alleviates symptoms of neurodegenerative diseases, cardiovascular diseases, and cancers. Considering the potential of β-HB and the intriguing data emerging from in vivo and in vitro experiments as well as clinical trials, this therapeutic area is worthy of attention. In this review, we highlight studies that focus on the identified targets of β-HB and the cellular signals regulated by β-HB with respect to alleviation of age-associated ailments.
衰老是一个普遍的过程，使个体易患许多疾病。虽然这个过程是不可逆转的，但饮食调节和热量限制通常被认为具有抗衰老作用。饮食调节可以增加并维持循环酮体，特别是β-羟丁酸（β-HB），它是人类循环中最丰富的酮体之一。有报道称，增加β-HB 可以预防或改善各种与年龄相关的疾病的症状。事实上，许多研究报告指出，生酮饮食或酮酯给药可以缓解神经退行性疾病、心血管疾病和癌症的症状。鉴于β-HB 的潜力以及体内和体外实验以及临床试验中出现的有趣数据，这个治疗领域值得关注。在这篇综述中，我们重点介绍了β-HB 针对与年龄相关疾病的缓解作用所针对的已确定靶点以及由β-HB 调节的细胞信号的研究。
