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本文引用的文献

1
Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation.衰弱和认知障碍与口服抗凝药在房颤患者中的获益的关系。
Am Heart J. 2019 May;211:77-89. doi: 10.1016/j.ahj.2019.01.005. Epub 2019 Jan 30.
2
Atrial fibrillation detection using single lead portable electrocardiographic monitoring: a systematic review and meta-analysis.使用单导联便携式心电图监测进行心房颤动检测:系统评价和荟萃分析。
BMJ Open. 2018 Sep 17;8(9):e024178. doi: 10.1136/bmjopen-2018-024178.
3
What is the Impact of Frailty on Prescription of Anticoagulation in Elderly Patients with Atrial Fibrillation? A Systematic Review and Meta-Analysis.衰弱对老年房颤患者抗凝治疗处方有何影响?一项系统评价和荟萃分析。
J Atr Fibrillation. 2018 Apr 30;10(6):1870. doi: 10.4022/jafib.1870. eCollection 2018 Apr.
4
Linking Atrial Fibrillation with Alzheimer's Disease: Epidemiological, Pathological, and Mechanistic Evidence.将心房颤动与阿尔茨海默病联系起来:流行病学、病理学和机制证据。
J Alzheimers Dis. 2018;62(1):61-72. doi: 10.3233/JAD-170970.
5
Does atrial fibrillation cause cognitive decline and dementia?心房颤动会导致认知能力下降和痴呆吗?
Europace. 2018 Mar 1;20(3):408-419. doi: 10.1093/europace/eux031.
6
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.2016年欧洲心脏病学会(ESC)与欧洲心胸外科学会(EACTS)合作制定的心房颤动管理指南。
Europace. 2016 Nov;18(11):1609-1678. doi: 10.1093/europace/euw295. Epub 2016 Aug 27.
7
Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review.心房颤动中的血栓预防及其与认知功能下降的关联:系统评价
Age Ageing. 2016 Nov;45(6):767-775. doi: 10.1093/ageing/afw104. Epub 2016 Jun 30.
8
Detection of Atrial Fibrillation with Intermittent Handheld Electrocardiogram in Patients with Ischemic Stroke and Transient Ischemic Attack.缺血性中风和短暂性脑缺血发作患者中使用间歇性手持式心电图检测心房颤动
J Stroke Cerebrovasc Dis. 2016 Nov;25(11):2648-2652. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.010. Epub 2016 Aug 1.
9
Yield of screening for atrial fibrillation in primary care with a hand-held, single-lead electrocardiogram device during influenza vaccination.在流感疫苗接种期间使用手持式单导联心电图设备在基层医疗中筛查心房颤动的检出率。
Europace. 2016 Oct;18(10):1514-1520. doi: 10.1093/europace/euv426. Epub 2016 Feb 6.
10
The Effect of Bleeding Risk and Frailty Status on Anticoagulation Patterns in Octogenarians With Atrial Fibrillation: The FRAIL-AF Study.出血风险和虚弱状态对老年房颤患者抗凝模式的影响:FRAIL-AF研究
Can J Cardiol. 2016 Feb;32(2):169-76. doi: 10.1016/j.cjca.2015.05.012. Epub 2015 May 27.

老年患者使用单导联设备进行房颤的机会性筛查。

Opportunistic screening for atrial fibrillation with a single lead device in geriatric patients.

作者信息

Zwart Lennaert Ar, Jansen René Wmm, Ruiter Jacob H, Germans Tjeerd, Simsek Suat, Hemels Martin Ew

机构信息

Department of Geriatric Medicine, North West Clinics, Wilhelminalaan, Alkmaar, the Netherlands.

Department of Geriatric Medicine, Dijklander Hospital, Maelsonstraat, Hoorn, the Netherlands.

出版信息

J Geriatr Cardiol. 2020 Mar;17(3):149-154. doi: 10.11909/j.issn.1671-5411.2020.03.007.

DOI:10.11909/j.issn.1671-5411.2020.03.007
PMID:32280331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7118016/
Abstract

OBJECTIVE

To determine the diagnostic yield of repeated screening for atrial fibrillation (AF) among geriatric patients.

METHODS

A pragmatic prospective cohort study into applying opportunistic screening for AF with a handheld single lead ECG device (SLD) in a geriatric cohort. Consecutive patients of 65 years old and older visiting the geriatric outpatient clinic were eligible for inclusion. A 12 lead ECG was performed, followed by measurements with the SLD during every visit to the geriatric outpatient clinic. A frailty index was based on the accumulation of deficits model.

RESULTS

478 patients were eligible. Patients were excluded if they did not give informed consent (17 patients), had a pacemaker or implantable cardioverter defibrillator (20 patients), or had incomplete medical files (two patients). After exclusion, 439 patients participated in this study. The mean age was 78 years (range 65 to 100 years), 54% were female. AF was known in 89 patients (20%), first detected on the baseline ECG in four patients (1%) and first detected with the SLD in 20 patients (5%) during follow up visits. Sensitivity of the SLD was 90.0%, specificity 99.0%, negative predictive value 99.7%, and positive predictive value 73.5%. Most patients (82%) with AF were frail and 53% were severely frail.

CONCLUSION

Repeated screening in geriatric patients has a five times higher diagnostic yield than usual care. It was easily combined with usual care. Because of the positive predictive value of 73.5%, it remains necessary to confirm AF with a 12 lead ECG or 24-h Holter monitoring.

摘要

目的

确定老年患者反复筛查心房颤动(AF)的诊断率。

方法

一项实用的前瞻性队列研究,对老年队列应用手持式单导联心电图设备(SLD)进行AF机会性筛查。65岁及以上连续就诊于老年门诊的患者符合纳入条件。先进行12导联心电图检查,随后在每次老年门诊就诊时使用SLD进行测量。衰弱指数基于缺陷累积模型。

结果

478例患者符合条件。若患者未签署知情同意书(17例)、有起搏器或植入式心律转复除颤器(20例)或医疗文件不完整(2例),则被排除。排除后,439例患者参与本研究。平均年龄为78岁(范围65至100岁),54%为女性。89例患者(20%)已知患有AF,4例患者(1%)在基线心电图上首次检测到AF,20例患者(5%)在随访期间首次通过SLD检测到AF。SLD的敏感性为90.0%,特异性为99.0%,阴性预测值为99.7%,阳性预测值为73.5%。大多数AF患者(82%)虚弱,53%严重虚弱。

结论

老年患者反复筛查的诊断率比常规护理高五倍。它很容易与常规护理相结合。由于阳性预测值为73.5%,仍有必要通过12导联心电图或24小时动态心电图监测来确诊AF。