Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS UMR 860, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, 45, rue des Saints Peres, 75006 Paris, France; CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
Drug Discov Today. 2020 Jun;25(6):1065-1073. doi: 10.1016/j.drudis.2020.03.009. Epub 2020 Apr 10.
Aptamers are RNA or DNA oligonucleotides interacting to form unique 3D target conformations with high affinity and specificity, and are emerging as a powerful class of ligands for therapeutic applications. In addition, dendrimers are well-defined nano-sized symmetric polymeric molecules. In this review, we provide an analysis of the use of dendrimers modified with aptamers as nonviral vectors to specifically target tumor cells. Various anticancer agents have been encapsulated with dendrimers complexing with aptamers, including epirubicin, camptothecin, Bcl-xL short hairpin (sh)RNA, and 5-fluorouracil rhodamine-labeled dextran. Other types of polymeric nanoparticle (NP)-aptamer bioconjugates have also been developed and loaded with Pt(IV) derivatives, to target specific tumor cells.
适体是与形成独特的 3D 目标构象具有高亲和力和特异性的 RNA 或 DNA 寡核苷酸，并且正在成为治疗应用的一类强大的配体。此外，树枝状大分子是具有明确定义的纳米级对称聚合物分子。在这篇综述中，我们分析了使用带有适体的树枝状大分子作为非病毒载体来特异性靶向肿瘤细胞的情况。已经将各种抗癌药物与与适体复合的树枝状大分子一起包封，包括表阿霉素、喜树碱、Bcl-xL 短发夹（sh）RNA 和 5-氟尿嘧啶罗丹明标记的葡聚糖。还开发了其他类型的聚合物纳米颗粒（NP）-适体生物缀合物，并加载了 Pt（IV）衍生物，以靶向特定的肿瘤细胞。
