Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Emerg Microbes Infect. 2020 Dec;9(1):924-927. doi: 10.1080/22221751.2020.1752610.
Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening.
由于分子检测的阳性率不理想，对 SARS-CoV-2 感染的确诊受到了挑战。在这里，我们鉴定了一个家庭聚集性的 SARS-CoV-2 感染，其中 6 个家庭成员中有 5 个 SARS-CoV-2 特异性免疫球蛋白血清学检测呈阳性，而分子检测仅在这 5 个患者中的 2 个中检测到，即使重复了两次也是如此。我们根据临床特征、胸部 CT 图像、SARS-CoV-2 分子检测结果和血清学检测结果，对这个家族聚集性病例进行了全面分析。最后，2 例患者被诊断为 COVID-19，2 例被怀疑为 COVID-19，2 例被认为是密切接触者。我们的结果强调了血清学检测在协助及时诊断 SARS-CoV-2 感染方面的重要性，特别是对 COVID-19 密切接触者的筛查。
