芳香族化合物微生物生产中常见的问题及相应的代谢工程策略。
Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic engineering strategies.
机构信息
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 135 Songling Road, Qingdao 266101, China; Energy-Rich Compound Production by Photosynthetic Carbon Fixation Research Center, College of Life Sciences, Qingdao Agricultural University, No. 700 Changchen Road, Qingdao 266109, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 135 Songling Road, Qingdao 266101, China.
出版信息
Biotechnol Adv. 2020 Jul-Aug;41:107548. doi: 10.1016/j.biotechadv.2020.107548. Epub 2020 Apr 11.
Recent progress in metabolic engineering and synthetic biology has enabled the production of valuable chemicals in microbial cell factories from renewable feedstocks. High value-added aromatic compounds, most of which are traditionally chemically synthesized from petroleum-derived feedstocks, represent a large class of chemicals with industrial significance. The microbial biosynthesis of aromatic compounds has been studied for decades, and varying yields have been achieved for different aromatic compounds. In this review, we describe the common problems associated with the microbial biosynthesis of diverse aromatic compounds and summarize the corresponding metabolic engineering strategies for resolving these problems. In addition, future perspectives on the microbial production of aromatic compounds are discussed.
近年来，代谢工程和合成生物学的进展使得人们能够利用可再生原料在微生物细胞工厂中生产有价值的化学品。高附加值芳香族化合物是工业上具有重要意义的一类化学品，其中大部分传统上是从石油衍生原料中通过化学合成方法得到的。几十年来，人们一直在研究微生物生物合成芳香族化合物，不同芳香族化合物的产量也有所不同。在本文中，我们描述了与微生物生物合成各种芳香族化合物相关的常见问题，并总结了相应的代谢工程策略来解决这些问题。此外，还讨论了芳香族化合物微生物生产的未来展望。
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