Zhang Lu, Cheng Qian, Li Chuxin, Zeng Xuan, Zhang Xian-Zheng
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.
Biomaterials. 2020 Jul;248:120029. doi: 10.1016/j.biomaterials.2020.120029. Epub 2020 Apr 7.
Although metal-based agents are widely used in disease treatment, precisely controlled metal ions release is still a challenge. Here, we demonstrated a nanoplatform (PAM) to achieve on-demand activation and release of metal ions via controlling oxidation condition by near infrared (NIR) light-inducted photodynamic therapy (PDT). PAM was constructed by decorating silver nanoparticles (AgNPs) onto the porphyrinic porous coordination network (PCN) and further camouflaging with the neutrophil membrane (NM) with inflammatory targeting ability. PAM was inactive without irradiation, causing no damage to normal tissues. However, under NIR irradiation at tumor or infected tissues, PCN locally generated singlet oxygen (O), enabling AgNPs to be partly degraded to release cytotoxic Ag for metal ions therapy (MIT). Simultaneously, the incorporated AgNPs promoted the O yield of PCN due to the localized electric field effect. Consequently, the NIR light-controlled interlocking interactions between AgNPs and PCN might offer a great potential for achieving controlled, precise and efficient disease treatment with reduced side-effect.
尽管金属基药物在疾病治疗中被广泛应用，但精确控制金属离子的释放仍然是一个挑战。在此，我们展示了一种纳米平台（PAM），通过近红外（NIR）光诱导光动力疗法（PDT）控制氧化条件，实现金属离子的按需激活和释放。PAM是通过将银纳米颗粒（AgNPs）修饰在卟啉多孔配位网络（PCN）上，并进一步用具有炎症靶向能力的中性粒细胞膜（NM）进行伪装而构建的。在没有照射的情况下，PAM没有活性，不会对正常组织造成损害。然而，在肿瘤或感染组织处进行近红外照射时，PCN会局部产生单线态氧（O），使AgNPs部分降解以释放具有细胞毒性的Ag用于金属离子疗法（MIT）。同时，由于局部电场效应，掺入的AgNPs提高了PCN的O产量。因此，AgNPs与PCN之间的近红外光控联锁相互作用可能为实现可控、精确和高效的疾病治疗并减少副作用提供巨大潜力。
