Gylling H, Miettinen T A
Second Department of Medicine, University of Helsinki, Finland.
Clin Chim Acta. 1988 Nov;178(1):41-9. doi: 10.1016/0009-8981(88)90267-7.
Serum cholesterol precursor levels and plant sterol were related to parameters of cholesterol metabolism in 22 patients with heterozygous familial hypercholesterolemia. The serum levels of cholesterol precursor sterols were inversely related to fractional absorption of dietary cholesterol and subsequently positively to overall cholesterol synthesis. The serum plant sterol levels, on the contrary, were significantly associated with fractional cholesterol absorption and negatively with overall cholesterol synthesis. These results were confirmed also with multivariate analyses. Fecal lanosterol, a cholesterol precursor, was related positively to cholesterol synthesis measured by sterol balance and serum precursors and negatively to serum plant sterols. The serum precursor and plant sterol levels were inversely significantly related to each other, indicating that the higher cholesterol absorption efficiency the higher are the serum plant sterol levels and the lower the precursor sterol contents and the overall cholesterol synthesis.
在22例杂合子家族性高胆固醇血症患者中，血清胆固醇前体水平和植物甾醇与胆固醇代谢参数相关。胆固醇前体甾醇的血清水平与膳食胆固醇的分数吸收呈负相关，随后与总胆固醇合成呈正相关。相反，血清植物甾醇水平与胆固醇分数吸收显著相关，与总胆固醇合成呈负相关。多变量分析也证实了这些结果。粪便羊毛甾醇是一种胆固醇前体，与通过甾醇平衡和血清前体测量的胆固醇合成呈正相关，与血清植物甾醇呈负相关。血清前体和植物甾醇水平彼此呈显著负相关，表明胆固醇吸收效率越高，血清植物甾醇水平越高，前体甾醇含量和总胆固醇合成越低。
