Whittet H B, Williams H O, Wright A
Royal National Throat, Nose and Ear Hospital, London.
Clin Otolaryngol Allied Sci. 1988 Dec;13(6):481-4. doi: 10.1111/j.1365-2273.1988.tb00321.x.
The relative efficiency of 2 topical anaesthetic agents in controlling the pain arising from myringotomy and grommet insertion has been assessed by a prospective, single blind controlled trial. The 2 anaesthetics were 5% cocaine and a new lignocaine and prilocaine mixture named Emla. Following a standardized anaesthetic procedure the pain arising from myringotomy, aspiration of the middle ear and subsequent insertion of a grommet was recorded by the patient on a linear analogue scale. A multivariate analysis was performed to assess the factors which significantly affected the pain levels. Only the type of anaesthetic used played a major role, with Emla giving significantly better anaesthesia than cocaine.
通过一项前瞻性单盲对照试验，评估了两种局部麻醉剂在控制鼓膜切开术和鼓膜置管术引起的疼痛方面的相对效率。这两种麻醉剂分别是5%的可卡因以及一种名为恩纳（Emla）的新型利多卡因和丙胺卡因混合物。按照标准化麻醉程序操作后，患者使用线性模拟量表记录鼓膜切开术、中耳抽吸以及随后鼓膜置管引起的疼痛。进行多变量分析以评估显著影响疼痛程度的因素。结果发现，仅所使用的麻醉剂类型起主要作用，恩纳的麻醉效果明显优于可卡因。
