Jyväkorpi M
Eur Arch Otorhinolaryngol. 1996;253(4-5):234-6. doi: 10.1007/BF00171133.
The purpose of this study was to investigate the relative efficacy of Emla cream (a eutectic formulation of lignocaine and prilocaine) and Bonain's solution (equal amounts of cocaine hydrochloride, menthol and phenol) as local anesthetic agents to the tympanic membrane. Fifty patients undergoing bilateral tympanocentesis were included. The patients were used as their own controls. One tympanic membrane was anesthetized with Emla cream and the other with Bonain's solution. The operating microscope was used. After a 30 min analgesic time, tympanocentesis was performed with aspiration of middle ear secretions. Each patient was then asked to fill in a questionnaire that graded the severity of pain experienced: none, very mild, mild, moderate or severe. Findings showed that Bonain's solution was more effective in tympanocentesis. All patients experienced no pain to very mild pain. With Emla cream 15 of 50 patients experienced mild to moderate pain. No significant side effects occurred with either anesthetic agent.
本研究旨在调查复方利多卡因乳膏（利多卡因和丙胺卡因的共熔混合物）和博纳因溶液（等量的盐酸可卡因、薄荷醇和苯酚）作为鼓膜局部麻醉剂的相对疗效。纳入了50例接受双侧鼓膜穿刺术的患者。患者自身作为对照。一侧鼓膜用复方利多卡因乳膏麻醉，另一侧用博纳因溶液麻醉。使用手术显微镜。在30分钟镇痛时间后，进行鼓膜穿刺术并抽吸中耳分泌物。然后要求每位患者填写一份问卷，对所经历的疼痛严重程度进行分级：无、非常轻微、轻微、中度或重度。结果显示，博纳因溶液在鼓膜穿刺术中更有效。所有患者经历的疼痛为无至非常轻微。使用复方利多卡因乳膏时，50例患者中有15例经历了轻至中度疼痛。两种麻醉剂均未出现明显副作用。
