• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

海洋生物衍生脂质体对两种人乳腺癌细胞系的影响。

Effects of ‎Bioactive ‎Marine-Derived ‎Liposomes on ‎Two ‎Human ‎Breast Cancer ‎‎Cell Lines.

机构信息

‎CRAN, CNRS-Université de Lorraine, F-54506 Vandœuvre-lès-Nancy, France.

‎LIBio, Université de Lorraine, F-54000 Nancy, France‎.

出版信息

Mar Drugs. 2020 Apr 13;18(4):211. doi: 10.3390/md18040211.

DOI:10.3390/md18040211
PMID:32295082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7230201/
Abstract

Breast cancer is the leading ‎cause of death from cancer ‎among women. Higher ‎consumption ‎of ‎dietary ‎marine n-3 long-chain ‎polyunsaturated fatty acids ‎‎(LC-PUFAs) is associated ‎with a ‎‎lower risk of breast ‎cancer. Eicosapentaenoic ‎acid (EPA) and ‎docosahexaenoic acid (DHA) ‎‎are ‎two n-3 LC-PUFAs found ‎in fish and exert anticancer ‎effects. In this study, ‎natural ‎marine-‎derived ‎lecithin that is rich in ‎various polyunsaturated fatty acids (PUFAs) was extracted ‎from salmon heads and ‎‎transformed ‎into ‎nanoliposomes. These ‎nanoliposomes were ‎characterized and cultured ‎with ‎two breast ‎cancer ‎lines (MCF-7 and MDA-MB-‎‎231). The nanoliposomes ‎decreased the ‎proliferation ‎and ‎the stiffness of both ‎cancer cell types. These ‎results suggest that marine-derived lecithin possesses ‎‎anticancer properties, ‎which may have an impact ‎on developing new ‎‎liposomal delivery ‎‎strategies for breast cancer ‎treatment.

摘要

乳腺癌是女性癌症死亡的主要原因。较高的饮食中摄入的海洋 n-3 长链多不饱和脂肪酸（LC-PUFAs）与乳腺癌风险降低相关。二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）是两种存在于鱼类中的 n-3 LC-PUFA，具有抗癌作用。在这项研究中，从三文鱼鱼头中提取了富含各种多不饱和脂肪酸（PUFAs）的天然海洋衍生卵磷脂，并将其转化为纳米脂质体。这些纳米脂质体进行了表征，并与两种乳腺癌细胞系（MCF-7 和 MDA-MB-231）进行了培养。纳米脂质体降低了这两种癌细胞类型的增殖和硬度。这些结果表明，海洋衍生卵磷脂具有抗癌特性，这可能对开发新的用于乳腺癌治疗的脂质体递送策略产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/cd10e6d6d7eb/marinedrugs-18-00211-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/9b26d87493ef/marinedrugs-18-00211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/cd5eb3d42f73/marinedrugs-18-00211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/359b21bd7cce/marinedrugs-18-00211-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/cd10e6d6d7eb/marinedrugs-18-00211-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/9b26d87493ef/marinedrugs-18-00211-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/cd5eb3d42f73/marinedrugs-18-00211-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/359b21bd7cce/marinedrugs-18-00211-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e936/7230201/cd10e6d6d7eb/marinedrugs-18-00211-g004.jpg

相似文献

1
Effects of ‎Bioactive ‎Marine-Derived ‎Liposomes on ‎Two ‎Human ‎Breast Cancer ‎‎Cell Lines.海洋生物衍生脂质体对两种人乳腺癌细胞系的影响。
Mar Drugs. 2020 Apr 13;18(4):211. doi: 10.3390/md18040211.
2
Long-chain Omega-3 Polyunsaturated Fatty Acids in Natural Ecosystems and the Human Diet: Assumptions and Challenges.长链ω-3 多不饱和脂肪酸在自然生态系统和人类饮食中的作用：假设与挑战。
Biomolecules. 2019 Sep 12;9(9):485. doi: 10.3390/biom9090485.
3
Comparative study of the oxidative and physical stability of liposomal and nanoliposomal polyunsaturated fatty acids prepared with conventional and Mozafari methods.常规法和 Mozafari 法制备的多不饱和脂肪酸脂质体和纳米脂质体的氧化和物理稳定性比较研究。
Food Chem. 2012 Dec 15;135(4):2761-70. doi: 10.1016/j.foodchem.2012.07.016. Epub 2012 Jul 14.
4
Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells.磷虾油提取物可抑制人结肠癌细胞的生长并诱导其凋亡。
BMC Complement Altern Med. 2016 Aug 30;16(1):328. doi: 10.1186/s12906-016-1311-x.
5
-3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer.-3 种多不饱和脂肪酸酰胺：预防和治疗乳腺癌的新途径。
Int J Mol Sci. 2020 Mar 26;21(7):2279. doi: 10.3390/ijms21072279.
6
Incorporation of eicosapentaenioic and docosahexaenoic acids into breast adipose tissue of women at high risk of breast cancer: a randomized clinical trial of dietary fish and n-3 fatty acid capsules.二十碳五烯酸和二十二碳六烯酸纳入乳腺癌高危女性乳腺脂肪组织的研究：饮食中鱼类及n-3脂肪酸胶囊的随机临床试验
Mol Nutr Food Res. 2015 Sep;59(9):1780-90. doi: 10.1002/mnfr.201500161. Epub 2015 Jul 7.
7
Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231.ω脂肪酸的差异比例（花生四烯酸/二十碳五烯酸+二十二碳六烯酸）调节乳腺癌细胞系MCF7和MDA-MB-231的生长、脂质过氧化及肿瘤调节MARBPs的表达。
PLoS One. 2015 Sep 1;10(9):e0136542. doi: 10.1371/journal.pone.0136542. eCollection 2015.
8
Docosahexaenoic Acid Incorporation Is Not Affected by Doxorubicin Chemotherapy in either Whole Cell or Lipid Raft Phospholipids of Breast Cancer Cells in vitro and Tumor Phospholipids in vivo.二十二碳六烯酸的掺入不受阿霉素化疗的影响，无论是在体外乳腺癌细胞的全细胞或脂筏磷脂中，还是在体内肿瘤磷脂中。
Lipids. 2020 Sep;55(5):549-565. doi: 10.1002/lipd.12252. Epub 2020 Jun 25.
9
E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro.源自南极磷虾的二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的电子构型结构及其对人癌细胞系体外生长的显著抑制作用。
Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:47-53. doi: 10.1016/j.plefa.2017.01.005. Epub 2017 Jan 25.
10
Hybrid striped bass feeds based on fish oil, beef tallow, and eicosapentaenoic acid/docosahexaenoic acid supplements: Insight regarding fish oil sparing and demand for -3 long-chain polyunsaturated fatty acids.以鱼油、牛脂和二十碳五烯酸/二十二碳六烯酸补充剂为基础的杂交条纹鲈饲料：关于节省鱼油和对ω-3长链多不饱和脂肪酸需求的见解。
J Anim Sci. 2016 Mar;94(3):978-88. doi: 10.2527/jas.2015-9199.

引用本文的文献

1
Chondroitin Sulfate Nanovectorized by LC-PUFAs Nanocarriers Extracted from Salmon () by Green Process with Decreased Inflammatory Marker Expression in Interleukin-1β-Stimulated Primary Human Chondrocytes In Vitro Culture.通过绿色工艺从三文鱼中提取的富含长链多不饱和脂肪酸（LC-PUFAs）的纳米载体对硫酸软骨素进行纳米载化，可降低白细胞介素-1β刺激的原代人软骨细胞体外培养中的炎症标志物表达。
Mar Drugs. 2024 Dec 20;22(12):571. doi: 10.3390/md22120571.
2
Recent Advances in Marine-Derived Nanoformulation for the Management of Glioblastoma.用于胶质母细胞瘤治疗的海洋来源纳米制剂的最新进展
Mol Biotechnol. 2024 Sep 26. doi: 10.1007/s12033-024-01287-3.
3

本文引用的文献

1
Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications.天然水凝胶的软纳米颗粒功能化及其在组织工程中的应用。
Adv Healthc Mater. 2019 Sep;8(18):e1900506. doi: 10.1002/adhm.201900506. Epub 2019 Aug 12.
2
Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments.壳聚糖包覆的载姜黄素纳米脂质体的制备、表征及在模拟环境中的释放动力学研究。
Molecules. 2019 May 27;24(10):2023. doi: 10.3390/molecules24102023.
3
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Marine bioactive peptides with anticancer potential, a narrative review.
具有抗癌潜力的海洋生物活性肽：一篇综述
Int J Biochem Mol Biol. 2024 Aug 25;15(4):118-126. doi: 10.62347/TUVQ7468. eCollection 2024.
4
Alzheimer's Disease: Treatment Strategies and Their Limitations.阿尔茨海默病：治疗策略及其局限性。
Int J Mol Sci. 2022 Nov 12;23(22):13954. doi: 10.3390/ijms232213954.
5
Transfer Phenomena of Nanoliposomes by Live Imaging of Primary Cultures of Cortical Neurons.通过皮质神经元原代培养物的实时成像观察纳米脂质体的转运现象
Pharmaceutics. 2022 Oct 12;14(10):2172. doi: 10.3390/pharmaceutics14102172.
6
Hybrid extracellular vesicles-liposome incorporated advanced bioink to deliver microRNA.杂交细胞外囊泡-脂质体复合的先进生物墨水用于递送 microRNA。
Biofabrication. 2022 Aug 19;14(4). doi: 10.1088/1758-5090/ac8621.
7
Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors.n-3 长链多不饱和脂肪酸对预防乳腺癌危险因素的贡献。
Int J Environ Res Public Health. 2022 Jun 28;19(13):7936. doi: 10.3390/ijerph19137936.
8
Efficient TGF-β1 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes.利用基于农业的脂质体在体外高效递送至关节软骨细胞的 TGF-β1。
Int J Mol Sci. 2022 Mar 5;23(5):2864. doi: 10.3390/ijms23052864.
9
Physicochemical Interactions in Nanofunctionalized Alginate/GelMA IPN Hydrogels.纳米功能化藻酸盐/甲基丙烯酸缩水甘油酯互穿聚合物网络水凝胶中的物理化学相互作用
Nanomaterials (Basel). 2021 Aug 31;11(9):2256. doi: 10.3390/nano11092256.
10
Gelatin Methacryloyl (GelMA) Nanocomposite Hydrogels Embedding Bioactive Naringin Liposomes.包埋生物活性柚皮苷脂质体的甲基丙烯酰化明胶（GelMA）纳米复合水凝胶
Polymers (Basel). 2020 Dec 9;12(12):2944. doi: 10.3390/polym12122944.
全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
4
Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies.通过改良乙醇注射法开发双药负载纳米脂质体制剂及其临床前药代动力学研究。
Pharmaceutics. 2018 Sep 6;10(3):151. doi: 10.3390/pharmaceutics10030151.
5
Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review.肿瘤微环境与癌症转移的生物物理学——一篇综述短文
Comput Struct Biotechnol J. 2018 Jul 27;16:279-287. doi: 10.1016/j.csbj.2018.07.003. eCollection 2018.
6
The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.姜黄素负载的三文鱼纳米脂体对原代皮质神经元培养的积极作用。
Mar Drugs. 2018 Jun 25;16(7):218. doi: 10.3390/md16070218.
7
ω-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy.ω-3 长链多不饱和脂肪酸作为癌症治疗中的敏化剂和多药耐药逆转剂。
Int J Mol Sci. 2017 Dec 20;18(12):2770. doi: 10.3390/ijms18122770.
8
Omega-3 free fatty acids attenuate insulin-promoted breast cancer cell proliferation.ω-3游离脂肪酸可减弱胰岛素促进的乳腺癌细胞增殖。
Nutr Res. 2017 Jun;42:43-50. doi: 10.1016/j.nutres.2017.04.008. Epub 2017 May 4.
9
A Study of the Differential Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) on Gene Expression Profiles of Stimulated Thp-1 Macrophages.二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）对刺激的Thp-1巨噬细胞基因表达谱的差异影响研究
Nutrients. 2017 Apr 25;9(5):424. doi: 10.3390/nu9050424.
10
Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel.使用大豆卵磷脂包裹紫杉醇的脂质体的研制及体外评价
Int J Biomater. 2017;2017:8234712. doi: 10.1155/2017/8234712. Epub 2017 Feb 26.