Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China.
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China.
ACS Appl Mater Interfaces. 2020 May 6;12(18):20191-20201. doi: 10.1021/acsami.0c02006. Epub 2020 Apr 27.
Inspired by the particularity of tumor microenvironments, including acidity and sensibility to reactive oxygen species (ROS), advanced and smart responsive nanomaterials have recently been developed. The present study synthesized tumor-targeted and pH-sensitive supramolecular micelles that self-assembled host-guest recognition. The micelles consumed intratumoral glucose and lactate loading with glucose oxidase (GOD) and lactate oxidase (LOD). Intratumoral glucose and lactate were converted into hydrogen peroxide (HO) and were sequentially reduced to highly toxic hydroxyl radicals (OH) the peroxidase (POD)-like activity of the loaded C-dot nanozymes. Tumor-killing effects were observed cascade catalytic reactions. After an intravenous injection, the nanocomposite exhibited an excellent tumor-targeted ability with good biocompatibility, which demonstrated its effective antitumor effect. The nanocomposite effectively combined starvation and catalytic therapies and exerted a synergistic anticancer effect with minimal side effects and without external addition.
受肿瘤微环境的特殊性启发，包括酸度和对活性氧（ROS）的敏感性，最近开发了先进的智能响应纳米材料。本研究合成了肿瘤靶向和 pH 敏感的超分子胶束，这些胶束通过主客体识别自组装。胶束消耗肿瘤内的葡萄糖和乳酸，并装载葡萄糖氧化酶（GOD）和乳酸氧化酶（LOD）。肿瘤内的葡萄糖和乳酸被转化为过氧化氢（HO），并被负载的 C 点纳米酶的过氧化物酶（POD）样活性依次还原为高毒性的羟基自由基（OH）。观察到级联催化反应的肿瘤杀伤作用。静脉注射后，该纳米复合材料表现出优异的肿瘤靶向能力和良好的生物相容性，证明了其有效的抗肿瘤作用。该纳米复合材料有效地将饥饿和催化疗法结合起来，并发挥协同抗癌作用，副作用最小，无需外部添加。
