Laboratório de Doenças Tropicais - Prof Luiz Jacintho da Silva Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil; Wellcome Center for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil; Instituto Leônidas and Maria Deane, Fiocruz Amazônia, Manaus, Brazil.
Trends Parasitol. 2020 May;36(5):447-458. doi: 10.1016/j.pt.2020.03.002. Epub 2020 Mar 31.
Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax.
基于循环生物标志物估计间日疟原虫生物量表明，存在一种主要的生物量存在于循环之外，而外周寄生虫血症无法捕捉到这一点，特别是在具有复杂结局的患者中。最近的一系列研究表明，骨髓（BM）的造血龛是寄生虫复制和传播阶段发展的主要储库。然而，我们对宿主-寄生虫相互作用、病理生理学以及对这种储库的治疗和诊断的意义的理解仍然存在重大知识差距。在这里，我们根据间日疟原虫讨论这一新兴研究领域的现状。
