白藜芦醇对变形链球菌致龋毒力特性的影响。
Effects of resveratrol on cariogenic virulence properties of Streptococcus mutans.
机构信息
Department of General Dentistry, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, 639 Zhi Zao Ju Road, Shanghai, 200011, China.
出版信息
BMC Microbiol. 2020 Apr 17;20(1):99. doi: 10.1186/s12866-020-01761-3.
BACKGROUND
Streptococcus mutans is the principal etiological agent of human dental caries. The major virulence factors of S. mutans are acid production, acid tolerance, extracellular polysaccharide (EPS) synthesis and biofilm formation. The aim of this study is to evaluate the effect of resveratrol, a natural compound, on virulence properties of S. mutans.
RESULTS
Resveratrol at sub-MIC levels significantly decreased acid production and acid tolerance, inhibited synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, compromised biofilm formation. Related virulence gene expression (ldh, relA, gtfC, comDE) was down-regulated with increasing concentrations of resveratrol.
CONCLUSIONS
Resveratrol has an inhibitory effect on S. mutans cariogenic virulence properties and it represents a promising anticariogenic agent.
背景
变形链球菌是人类龋齿的主要病原体。变形链球菌的主要毒力因子是产酸、耐酸、细胞外多糖（EPS）合成和生物膜形成。本研究旨在评估白藜芦醇这一天然化合物对变形链球菌毒力特性的影响。
结果
亚 MIC 水平的白藜芦醇显著降低产酸和耐酸能力，抑制水溶性多糖和不溶性多糖的合成，破坏生物膜形成。随着白藜芦醇浓度的增加，相关毒力基因（ldh、relA、gtfC、comDE）的表达下调。
结论
白藜芦醇对变形链球菌致龋毒力特性具有抑制作用，是一种很有前途的抗龋剂。
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