Rodighiero Eleonora, Bertolani Mariabeatrice, Saleri Roberta, Pedrazzi Giuseppe, Lotti Torello, Feliciani Claudio, Satolli Francesca
Section of Dermatology, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Department of Veterinary Science, University of Parma, Parma, Italy.
Dermatol Ther. 2020 May;33(3):e13439. doi: 10.1111/dth.13439. Epub 2020 May 19.
Acne is a chronic inflammatory disease affecting sebaceous gland follicles. Lately, acne has considered an insulin-like growth factor-1 (IGF-1) mediated disease. Recent research demonstrated that IGF-1 levels decrease after 3 months of isotretinoin. The purpose of our study is evaluating the influence of acne treatments on IGF-1 serum levels. Forty-six subjects with acne vulgaris aged 14 to 30 years were subdivided into three groups according to their severity of acne and treated following the European Dermatology Forum guidelines. IGF-1 was measured in patients before and after the treatment and then compared to the IGF-1 of a healthy population of the same age. IGF-1 resulted higher in patients than in controls but there was not a statistically significant variation after treatment. To the best of our knowledge, this is the first study evaluating the influence of topical and systemic acne treatment on IGF-1 serum levels. In contrast with the literature, our results suggest that common therapies for acne are not able to significantly modify IGF-1 serum levels.
痤疮是一种影响皮脂腺毛囊的慢性炎症性疾病。最近，痤疮被认为是一种由胰岛素样生长因子-1（IGF-1）介导的疾病。最近的研究表明，异维A酸治疗3个月后IGF-1水平会下降。我们研究的目的是评估痤疮治疗对血清IGF-1水平的影响。46名年龄在14至30岁的寻常痤疮患者根据痤疮严重程度分为三组，并按照欧洲皮肤病学论坛指南进行治疗。在治疗前后对患者进行IGF-1检测，然后与同年龄健康人群的IGF-1进行比较。患者的IGF-1水平高于对照组，但治疗后无统计学显著差异。据我们所知，这是第一项评估局部和全身痤疮治疗对血清IGF-1水平影响的研究。与文献相反，我们的结果表明，常见的痤疮治疗方法无法显著改变血清IGF-1水平。
