Rao H Y
Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, China.
Zhonghua Gan Zang Bing Za Zhi. 2020 Mar 20;28(3):278-283. doi: 10.3760/cma.j.cn50113-20190719-00255.
Over the past two decades, the incidence of non-alcoholic fatty liver disease (NAFLD) has risen sharply and has become the most common chronic liver disease, placing a heavy burden on patients and their families. A comprehensive assessment of the quality of life (QoL) of NAFLD patients is necessary to develop and implement more effective intervention strategies. Currently, the disease-specific scales commonly used to assess the quality of life of NAFLD patients include the 36-Item Short-Form Health Survey questionnaire (SF-36), Chronic Liver Disease Questionnaire (CLDQ), and so on. The research results of home and abroad showed that the quality of life of NAFLD patients is significantly lower than that of healthy people, and with the aggravation of the disease, the quality of life of such patients decreases, and may even be lower than other patients with chronic liver disease, and the reason for this may be related to factors such as body mass index (BMI) and complications. In clinical practice, the assessment of quality of life can fully reflect the health status of NAFLD patients, thereby helping to establish the personalized treatment goals to comprehensively assess the impact of disease on patients with clinical interventions.
在过去二十年中，非酒精性脂肪性肝病（NAFLD）的发病率急剧上升，已成为最常见的慢性肝病，给患者及其家庭带来了沉重负担。对NAFLD患者的生活质量（QoL）进行全面评估对于制定和实施更有效的干预策略是必要的。目前，常用于评估NAFLD患者生活质量的疾病特异性量表包括36项简短健康调查问卷（SF-36）、慢性肝病问卷（CLDQ）等。国内外研究结果表明，NAFLD患者的生活质量显著低于健康人，并且随着疾病的加重，此类患者的生活质量下降，甚至可能低于其他慢性肝病患者，其原因可能与体重指数（BMI）和并发症等因素有关。在临床实践中，生活质量评估可以充分反映NAFLD患者的健康状况，从而有助于确立个性化治疗目标，以全面评估疾病对患者的影响并进行临床干预。
