Edrada Edna M, Lopez Edmundo B, Villarama Jose Benito, Salva Villarama Eumelia P, Dagoc Bren F, Smith Chris, Sayo Ana Ria, Verona Jeffrey A, Trifalgar-Arches Jamie, Lazaro Jezreel, Balinas Ellen Grace M, Telan Elizabeth Freda O, Roy Lynsil, Galon Myvie, Florida Carl Hill N, Ukawa Tatsuya, Villaneuva Annavi Marie G, Saito Nobuo, Nepomuceno Jean Raphael, Ariyoshi Koya, Carlos Celia, Nicolasora Amalea Dulcene, Solante Rontgene M
San Lazaro Hospital, Manila, Philippines.
2School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Trop Med Health. 2020 Apr 14;48:21. doi: 10.1186/s41182-020-00203-0. eCollection 2020.
The novel coronavirus (COVID-19) is responsible for more fatalities than the SARS coronavirus, despite being in the initial stage of a global pandemic. The first suspected case in the Philippines was investigated on January 22, 2020, and 633 suspected cases were reported as of March 1. We describe the clinical and epidemiological aspects of the first two confirmed COVID-19 cases in the Philippines, both admitted to the national infectious disease referral hospital in Manila.
Both patients were previously healthy Chinese nationals on vacation in the Philippines travelling as a couple during January 2020. Patient 1, a 39-year-old female, had symptoms of cough and sore throat and was admitted to San Lazaro Hospital in Manila on January 25. Physical examination was unremarkable. , human coronavirus 229E, and were detected by PCR on initial nasopharyngeal/oropharyngeal (NPS/OPS) swabs. On January 30, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs and she was identified as the first confirmed COVID-19 case in the Philippines. Her symptoms resolved, and she was discharged. Patient 2, a 44-year-old male, had symptoms of fever, cough, and chills. and were detected by PCR on initial NPS/OPS swabs. He was treated for community-acquired pneumonia with intravenous antibiotics, but his condition deteriorated and he required intubation. On January 31, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs, and he was identified as the 2nd confirmed COVID-19 infection in the Philippines. On February 1, the patient's condition deteriorated, and following a cardiac arrest, it was not possible to revive him. He was thus confirmed as the first COVID-19 death outside of China.
This case report highlights several important clinical and public health issues. Despite both patients being young adults with no significant past medical history, they had very different clinical courses, illustrating how COVID-19 can present with a wide spectrum of disease. As of March 1, there have been three confirmed COVID-19 cases in the Philippines. Continued vigilance is required to identify new cases.
新型冠状病毒（COVID-19）尽管仍处于全球大流行的初期阶段，但已造成比严重急性呼吸综合征冠状病毒更多的死亡病例。菲律宾的首例疑似病例于2020年1月22日接受调查，截至3月1日共报告了633例疑似病例。我们描述了菲律宾首批两例确诊的COVID-19病例的临床和流行病学情况，这两例患者均入住了马尼拉的国家传染病转诊医院。
两名患者均为此前健康的中国公民，于2020年1月期间在菲律宾度假，二人结伴旅行。患者1为一名39岁女性，有咳嗽和咽痛症状，于1月25日入住马尼拉的圣拉萨罗医院。体格检查无异常。初次鼻咽/口咽拭子（NPS/OPS）的聚合酶链反应（PCR）检测发现了人冠状病毒229E、 和 。1月30日，初次拭子的PCR检测报告称检测到严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒RNA，她被确诊为菲律宾首例COVID-19病例。她的症状缓解后出院。患者2为一名44岁男性，有发热、咳嗽和寒战症状。初次NPS/OPS拭子的PCR检测发现了 和 。他因社区获得性肺炎接受静脉抗生素治疗，但病情恶化，需要插管。1月31日，初次拭子的PCR检测报告称检测到SARS-CoV-2病毒RNA，他被确诊为菲律宾第2例COVID-19感染病例。2月1日，患者病情恶化，心脏骤停后未能复苏。因此，他被确认为中国境外首例COVID-19死亡病例。
本病例报告突出了几个重要的临床和公共卫生问题。尽管两名患者均为无重大既往病史的年轻人，但他们的临床病程却大不相同，这说明了COVID-19的临床表现具有广泛的多样性。截至3月1日，菲律宾已有3例确诊的COVID-19病例。需要持续保持警惕以发现新病例。
