福氏志贺菌2A毒素的生物学特性及其与痢疾志贺菌1型毒素的血清学关系。
Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin.
作者信息
O'Brien A D, Thompson M R, Gemski P, Doctor B P, Formal S B
出版信息
Infect Immun. 1977 Mar;15(3):796-8. doi: 10.1128/iai.15.3.796-798.1977.
Abstract
A toxin extracted from heat-inactivated, alkaline-treated Shigella flexneri 2a showed biological properties similar to those of Shigella dysenteria 1 toxin. The S, flexneri 2a toxin was lethal to mice, enterotoxic for ileal loops of rabbits, and cytotoxic for HeLa cells. A serological relationship between S. flexneri 2a and S. dysenteriae 1 toxin was shown with cross neutralization tests.
摘要
从经热灭活和碱处理的福氏志贺菌2a中提取的一种毒素，其生物学特性与痢疾志贺菌1型毒素相似。福氏志贺菌2a毒素对小鼠具有致死性，对兔回肠袢具有肠毒性，对HeLa细胞具有细胞毒性。交叉中和试验表明福氏志贺菌2a与痢疾志贺菌1型毒素之间存在血清学关系。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
USE OF LIGATED SEGMENTS OF RABBIT SMALL INTESTINE IN EXPERIMENTAL SHIGELLOSIS.兔小肠结扎段在实验性志贺氏菌病中的应用
J Bacteriol. 1965 Mar;89(3):803-9. doi: 10.1128/jb.89.3.803-809.1965.
3
Studies with Vibrio cholerae in the ligated loop of the rabbit intestine.在兔肠结扎肠袢中对霍乱弧菌进行的研究。
Br J Exp Pathol. 1961 Oct;42(5):504-10.
4
The action of the thermolabile toxin of Shigella dysenteriae on cells cultivated in vitro.痢疾志贺氏菌不耐热毒素对体外培养细胞的作用。
Br J Exp Pathol. 1960 Apr;41(2):179-89.
5
The neurotoxin of Shigella shigae. I. Production, purification and properties of the toxin.痢疾志贺氏菌的神经毒素。I. 毒素的产生、纯化及性质
Br J Exp Pathol. 1953 Apr;34(2):202-16.
6
Fluorescent-antibody and histological study of vaccinated and control monkeys challenged with Shigella flexneri.用弗氏志贺菌攻击的接种疫苗和对照猴的荧光抗体及组织学研究。
J Bacteriol. 1966 Jun;91(6):2368-76. doi: 10.1128/jb.91.6.2368-2376.1966.
7
The pathogenesis of Shigella diarrhea. I. Enterotoxin production by Shigella dysenteriae I.志贺氏菌腹泻的发病机制。一、痢疾志贺氏菌I型产生肠毒素。
J Clin Invest. 1972 May;51(5):1212-8. doi: 10.1172/JCI106915.
8
Shigellosis due to Shigella dysenteriae. 1. Relative importance of mucosal invasion versus toxin production in pathogenesis.由痢疾志贺菌引起的志贺氏菌病。1. 黏膜侵袭与毒素产生在发病机制中的相对重要性。
J Infect Dis. 1972 Nov;126(5):523-30. doi: 10.1093/infdis/126.5.523.
9
Inhibition of in vitro protein synthesis by Shigella dysenteriae 1 toxin.痢疾志贺氏菌1型毒素对体外蛋白质合成的抑制作用。
Biochem Biophys Res Commun. 1976 Aug 9;71(3):783-8. doi: 10.1016/0006-291x(76)90899-8.
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