Formal S B, Kent T H, Austin S, Labrec E H
J Bacteriol. 1966 Jun;91(6):2368-76. doi: 10.1128/jb.91.6.2368-2376.1966.
Formal, Samuel B., (Walter Reed Army Institute of Research, Washington, D.C.), T. H. Kent, S. Austin, and E. H. LaBrec. Fluorescent-antibody and histological study of vaccinated and control monkeys challenged with Shigella flexneri. J. Bacteriol. 91:2368-2376. 1966.-Groups of monkeys were fed four doses of a living Escherichia coli-Shigella flexneri 2a hybrid strain, and, together with control animals, were challenged with virulent S. flexneri 2a. Two experiments were carried out; in the first, the animals were challenged 10 days after and in the second, 1 month after the last vaccine dose was administered. At 48 hr after challenge, tissues were removed from the vaccinated and control animals, and examined by use of histological and fluorescent-antibody techniques. The results of this study demonstrate that the animals receiving the vaccine were protected from the tissue damage ordinarily observed after experimental challenge with virulent dysentery bacilli. The virulent challenge strain appeared to be unable to penetrate into the intestinal mucosa of immunized animals.
福尔摩，塞缪尔·B.，（华盛顿特区沃尔特·里德陆军研究所），T.H.肯特，S.奥斯汀，以及E.H.拉布雷克。用弗氏志贺菌攻击的接种疫苗和对照猴子的荧光抗体及组织学研究。《细菌学杂志》91:2368 - 2376。1966年。——给几组猴子喂食四剂活的大肠杆菌 - 弗氏志贺菌2a杂交菌株，并与对照动物一起用强毒弗氏志贺菌2a进行攻击。进行了两项实验；在第一项实验中，动物在最后一剂疫苗接种后10天受到攻击，在第二项实验中，在最后一剂疫苗接种后1个月受到攻击。在攻击后48小时，从接种疫苗和对照动物身上取出组织，并用组织学和荧光抗体技术进行检查。这项研究的结果表明，接受疫苗的动物免受了在用强毒痢疾杆菌进行实验性攻击后通常观察到的组织损伤。强毒攻击菌株似乎无法穿透免疫动物的肠黏膜。
