• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

性别决定基因通过性二态神经元显著调节求偶能力和目标偏好。

Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.

机构信息

Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, United States.

Neuroscience Graduate Program, University of California, San Diego, San Diego, United States.

出版信息

Elife. 2020 Apr 21;9:e52701. doi: 10.7554/eLife.52701.

DOI:10.7554/eLife.52701
PMID:32314964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7173972/
Abstract

For successful mating, a male animal must execute effective courtship behaviors toward a receptive target sex, which is female. Whether the courtship execution capability and upregulation of courtship toward females are specified through separable sex-determining genetic pathways remains uncharacterized. Here, we found that one of the two sex-determining genes, (), specifies a male-specific neuronal component that serves as an execution mechanism for courtship behavior, whereas () is required for enhancement of courtship behavior toward females. The -dependent courtship execution mechanism includes a specific subclass within a neuronal cluster that co-express and . This cluster contains at least another subclass that is specified cooperatively by both and . Although these neuronal populations can also promote aggressive behavior toward male flies, this capacity requires -dependent mechanisms. Our results uncover how sex-determining genes specify execution capability and female-specific enhancement of courtship behavior through separable yet cooperative neurogenetic mechanisms.

摘要

为了成功交配，雄性动物必须对可接受的雌性目标执行有效的求爱行为。求爱执行能力和对雌性求爱的上调是否通过可分离的性别决定遗传途径来指定，目前仍不清楚。在这里，我们发现两个性别决定基因之一（）指定了一个雄性特异性神经元成分，作为求爱行为的执行机制，而（）则是增强对雌性求爱的必要条件。依赖的求爱执行机制包括一个神经元簇内的一个特定子类，该子类共同表达和。这个簇至少还包含另一个子类，它是由和共同指定的。尽管这些神经元群体也可以促进雄性苍蝇的攻击行为，但这种能力需要依赖的机制。我们的研究结果揭示了性别决定基因如何通过可分离但协作的神经遗传机制来指定求爱行为的执行能力和雌性特异性增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/9a59a1f9ecd6/elife-52701-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b5a0c39c9d5e/elife-52701-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/1b4eb90fb795/elife-52701-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/872fbcddc74e/elife-52701-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/e89b34eb9536/elife-52701-fig1-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/de67a3f08685/elife-52701-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/3487b38f17da/elife-52701-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/53d90cf90398/elife-52701-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/aa6c4416506c/elife-52701-fig2-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/be9d50928d04/elife-52701-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/bae636a4a2a2/elife-52701-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b3bdbcb71b80/elife-52701-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/ea401a200788/elife-52701-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/744ebaafe448/elife-52701-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/4a424c35b1b4/elife-52701-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/a59ca3a8189a/elife-52701-fig5-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/25511eb7061b/elife-52701-fig5-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/74129f3adecc/elife-52701-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b7331e28cba0/elife-52701-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/9a59a1f9ecd6/elife-52701-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b5a0c39c9d5e/elife-52701-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/1b4eb90fb795/elife-52701-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/872fbcddc74e/elife-52701-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/e89b34eb9536/elife-52701-fig1-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/de67a3f08685/elife-52701-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/3487b38f17da/elife-52701-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/53d90cf90398/elife-52701-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/aa6c4416506c/elife-52701-fig2-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/be9d50928d04/elife-52701-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/bae636a4a2a2/elife-52701-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b3bdbcb71b80/elife-52701-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/ea401a200788/elife-52701-fig4-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/744ebaafe448/elife-52701-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/4a424c35b1b4/elife-52701-fig5-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/a59ca3a8189a/elife-52701-fig5-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/25511eb7061b/elife-52701-fig5-figsupp3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/74129f3adecc/elife-52701-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/b7331e28cba0/elife-52701-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/735d/7173972/9a59a1f9ecd6/elife-52701-fig6-figsupp2.jpg

相似文献

1
Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.性别决定基因通过性二态神经元显著调节求偶能力和目标偏好。
Elife. 2020 Apr 21;9:e52701. doi: 10.7554/eLife.52701.
2
The sex-determination genes fruitless and doublesex specify a neural substrate required for courtship song.性别决定基因无果基因和双性基因指定了求偶鸣叫所需的神经基质。
Curr Biol. 2007 Sep 4;17(17):1473-8. doi: 10.1016/j.cub.2007.07.047. Epub 2007 Aug 23.
3
Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila.调控果蝇睡眠与性行为之间性别特异性相互作用的遗传和神经元机制。
Nat Commun. 2017 Jul 28;8(1):154. doi: 10.1038/s41467-017-00087-5.
4
Layered roles of isoforms in specification and function of male aggression-promoting neurons in .同种型在[具体物种]雄性攻击促进神经元的特化和功能中的分层作用。 （注：原文中“in.”后面缺少具体内容，这里根据语境补充了“[具体物种]”，以使译文更完整）
Elife. 2020 Apr 21;9:e52702. doi: 10.7554/eLife.52702.
5
Neuroethology of male courtship in Drosophila: from the gene to behavior.果蝇雄性求偶行为的神经行为学：从基因到行为
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2014 Apr;200(4):251-64. doi: 10.1007/s00359-014-0891-5. Epub 2014 Feb 25.
6
The gene regulates dimorphic sexual and aggressive behaviors in .该基因调控 的二态性性和攻击行为。
Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2201513119. doi: 10.1073/pnas.2201513119. Epub 2022 Sep 6.
7
Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction.果蝇求偶行为受 Tlx/同源异型盒基因 tailless 样核受体不满意调控
Curr Biol. 2022 Apr 25;32(8):1703-1714.e3. doi: 10.1016/j.cub.2022.02.031. Epub 2022 Mar 3.
8
The roles of fruitless and doublesex in the control of male courtship.fruitless 和 doublesex 在控制雄性求偶行为中的作用。
Int Rev Neurobiol. 2011;99:87-105. doi: 10.1016/B978-0-12-387003-2.00004-5.
9
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior.无果异构体和靶基因决定了果蝇生殖行为背后的性别二态神经系统。
Fly (Austin). 2014;8(2):95-100. doi: 10.4161/fly.29132.
10
Turning males on: activation of male courtship behavior in Drosophila melanogaster.使雄性兴奋：黑腹果蝇雄性求偶行为的激活。
PLoS One. 2011;6(6):e21144. doi: 10.1371/journal.pone.0021144. Epub 2011 Jun 22.

引用本文的文献

1
Sequencing of distinct wing behaviors during courtship.求偶过程中不同翅膀行为的测序。
bioRxiv. 2025 Aug 25:2025.08.21.671456. doi: 10.1101/2025.08.21.671456.
2
Male-male interactions shape mate selection in Drosophila.雄性间的相互作用影响果蝇的配偶选择。
Cell. 2025 Mar 20;188(6):1486-1503.e25. doi: 10.1016/j.cell.2025.01.008. Epub 2025 Feb 13.
3
A modular circuit coordinates the diversification of courtship strategies.模块化电路协调求偶策略的多样化。

本文引用的文献

1
An unbiased template of the Drosophila brain and ventral nerve cord.果蝇大脑和腹神经索的无偏模板。
PLoS One. 2020 Dec 31;15(12):e0236495. doi: 10.1371/journal.pone.0236495. eCollection 2020.
2
The neural basis for a persistent internal state in females.女性持续内在状态的神经基础。
Elife. 2020 Nov 23;9:e59502. doi: 10.7554/eLife.59502.
3
Layered roles of isoforms in specification and function of male aggression-promoting neurons in .同种型在[具体物种]雄性攻击促进神经元的特化和功能中的分层作用。 （注：原文中“in.”后面缺少具体内容，这里根据语境补充了“[具体物种]”，以使译文更完整）
Nature. 2024 Nov;635(8037):142-150. doi: 10.1038/s41586-024-08028-1. Epub 2024 Oct 9.
4
Neurons Underlying Aggression-Like Actions That Are Shared by Both Males and Females in .雄性和雌性动物共有的具有攻击性的行为的神经基础。
J Neurosci. 2024 Oct 30;44(44):e0142242024. doi: 10.1523/JNEUROSCI.0142-24.2024.
5
Transcriptional profiling of male-specific P1 (pC1) neurons.雄性特异性P1（pC1）神经元的转录谱分析。
bioRxiv. 2023 Nov 10:2023.11.07.566045. doi: 10.1101/2023.11.07.566045.
6
Male-male interactions shape mate selection in .雄性之间的互动影响着……中的配偶选择。
bioRxiv. 2023 Nov 5:2023.11.03.565582. doi: 10.1101/2023.11.03.565582.
7
A modular circuit architecture coordinates the diversification of courtship strategies in .一种模块化电路架构协调了求偶策略的多样化。 （原文中“in”后面缺少具体内容）
bioRxiv. 2023 Sep 17:2023.09.16.558080. doi: 10.1101/2023.09.16.558080.
8
Cell assembly analysis of neural circuits for innate behavior in using an immediate early gene /.利用即时早期基因对先天行为的神经回路进行细胞组装分析。
Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303318120. doi: 10.1073/pnas.2303318120. Epub 2023 Aug 7.
9
Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte Nuclear Factor 4.通过 Fruitless 和 Hepatocyte Nuclear Factor 4 整合脂质代谢、信息素产生和感知。
Sci Adv. 2023 Jun 30;9(26):eadf6254. doi: 10.1126/sciadv.adf6254.
10
Tachykininergic Neurons Modulate the Activity of Two Groups of Receptor-Expressing Neurons to Regulate Aggressive Tone.速激肽能神经元调节两组表达受体的神经元的活动以调节攻击音调。
J Neurosci. 2023 May 10;43(19):3394-3420. doi: 10.1523/JNEUROSCI.1734-22.2023. Epub 2023 Mar 28.
Elife. 2020 Apr 21;9:e52702. doi: 10.7554/eLife.52702.
4
Neural circuitry linking mating and egg laying in Drosophila females.果蝇雌雄交配和产卵的神经回路。
Nature. 2020 Mar;579(7797):101-105. doi: 10.1038/s41586-020-2055-9. Epub 2020 Feb 26.
5
Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila.在果蝇中，神经元在积分器中发挥作用，以促进持久的行为状态。
Neuron. 2020 Jan 22;105(2):322-333.e5. doi: 10.1016/j.neuron.2019.10.028. Epub 2019 Dec 3.
6
Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual Behavior.神经回路的周期性重塑控制雌性性行为的时间。
Cell. 2019 Nov 27;179(6):1393-1408.e16. doi: 10.1016/j.cell.2019.10.025. Epub 2019 Nov 14.
7
Shared Song Detector Neurons in Drosophila Male and Female Brains Drive Sex-Specific Behaviors.果蝇雌雄大脑中的共享歌曲探测器神经元驱动特定性别行为。
Curr Biol. 2019 Oct 7;29(19):3200-3215.e5. doi: 10.1016/j.cub.2019.08.008. Epub 2019 Sep 26.
8
Gain control in the sensorimotor system.在感觉运动系统中获得控制。
Curr Opin Physiol. 2019 Apr;8:177-187. doi: 10.1016/j.cophys.2019.03.005. Epub 2019 Mar 22.
9
A small number of cholinergic neurons mediate hyperaggression in female .少量胆碱能神经元介导雌性动物的过度攻击行为。
Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17029-17038. doi: 10.1073/pnas.1907042116. Epub 2019 Aug 7.
10
Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals.社会性互动动物大脑中相关的神经活动和行为编码。
Cell. 2019 Jul 11;178(2):429-446.e16. doi: 10.1016/j.cell.2019.05.022. Epub 2019 Jun 20.