Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid - Consejo Superior de Investigaciones Científicas, 28049, Madrid, Spain.
Biol Direct. 2020 Apr 21;15(1):7. doi: 10.1186/s13062-020-00262-7.
The archaea-bacteria lipid divide is one of the big evolutionary enigmas concerning these two domains of life. In short, bacterial membranes are made of fatty-acid esters whereas archaeal ones contain isoprenoid ethers, though at present we do not have a good understanding on why they evolved differently. The lateral proton transfer mode of energy transduction in membranes posits that protons utilize the solvation layer of the membrane interface as the main route between proton pumps and ATPases, avoiding dissipation of energy to the bulk phase. In this article I present the hypothesis on a proton-transport route through the ester groups of bacterial phospholipids as an explanation for the evolutionary divergence seen between bacteria and archaea. REVIEWERS: This article was reviewed by Uri Gophna (Editorial Board member) and Víctor Sojo.
古菌与细菌的脂质鸿沟是这两个生命领域的重大进化之谜之一。简而言之，细菌的膜由脂肪酸酯组成，而古菌的膜则含有异戊烯基醚，尽管目前我们还不太理解它们为什么会进化得如此不同。膜中能量传递的横向质子转移模式假设质子利用膜界面的溶剂化层作为质子泵和 ATP 酶之间的主要途径，从而避免能量耗散到主体相。在本文中，我提出了一种质子通过细菌磷脂的酯基团的传输途径的假说，以解释细菌和古菌之间的进化分歧。
Uri Gophna（编委成员）和 Víctor Sojo。
